Correlation Between Levels Of Lipoprotein-associated Phospholipase A2 And Vascular Complications In Patients With Type 2 Diabetes Mellitus

ObjectiveDiabetes mellitus is today seriously affect people's health, quality of life and life expectancy, one of the diseases, and its vascular complications in patients with type 2 diabetes, disability and mortality. High levels of type 2 diabetes mellitus inflammatory response, inflammation and diabetes and its vascular complications and development are closely related. Lipoprotein associated phospholipase A2 (LP-PLA2) is a newly discovered in atherosclerosis (AS) during the development of an enzyme closely related with the inflammatory response. To explore the correlation between levels of LP-PLA2 and vascular complications in patients with type 2 diabetes mellitus(T2DM),comprehend its clinical value.Methods2009.8-2010.6 clinical specimens from 180 patients with the Second Hospital of Shanxi Medical University, blood samples from diabetic patients, recording age, gender, body mass index, smoking history, family history, glycemic control, blood lipids, serum creatinine, urea nitrogen and urinary microalbumin Protein and other related data.180 cases were devided into 3 groups: T2DM and coronary atherosclerotic heart disease(CAD) group(48 cases),T2DM and Renal disease(RD) group(59 cases) and non-angiopathy group(73 cases).The serum LP-PLA2 levels in the above 3 groups and control group,60 healthy individuals. were measured. Determined by ELISA in serum LP-PLA2 concentrationResults(1)The LP-PLA2 levels in T2DM and CAD,T2DM and RD, non-angiopathy and group respectively, which were significantly higher than in control(P<0.05).(2)The LP-PLA2 levels in T2DMand CAD, T2DM and RD are higher than non-angiopathy group(P<0.01). (3)There was a positive collection between the LP-PLA2 level and the degree of body mass index(BMI),low density lipoprotein cholesterol(LDL),fasting blood glucose(FPG).Conclusions(1)The serum LP-PLA2 level is significantly associated with vascular complications in patients with T2DM , which can serve as a biomarker for monitoring the change of illness severity and early vascular complications in patients with T2DM.(2) LP-PLA2 in each group is different in vascular complications of diabetes , this can be used as an independent inflammatory markers(3)LP-PLA2 can be used for risk stratification in diabetes inflammatory factors...