Influence Of Sufentanil On Isolated Thoracic Aorta Contractile Function Of Spontaneous Hypertension Rat

.Object: Investigate the effect of sufentanil on norepinephrine-induced contraction ofinisolated thoracic aorta rings of Spontaneous Hypertension Rats(SHR)and NormotensiveRats(NTR).Methods: There were 8 spontaneous hypertension rats and 8 normotensive rats, take 4pieces of isolated thoracic aorta rings from each of them. Those rings of SHR were randomlydivided into 4 groups(n=8):physiological saline control group(group NC), sufentanil group 1(group NS1) , sufentanil group 2 (group NS2), sufentanil group3(group NS3). Those rings ofNTR were randomly divided into 4 groups(n=8):physiological saline control group(group SC),sufentanil group 1 (group SS1) , sufentanil group 2 (group SS2), sufentanil group3(groupSS3).Aortic rings were suspended for isometric tension recording. G1 is the vascular tensionafter adding 60 mmol/l KCl. Wash out the Kcl, vascular tension (G2) for norepinephrine (10^–8to 10^–5 M) were gener ated in the presence and absence of physiological saline and sufentanil(7×10^–11,2×10^–10,1×10^–9 M).Use G₂/ G₁×100% said the vasoconstriction amplitude.Investigate the effect of sufentanil on norepinephrine-induced contraction in SpontaneousHypertension Rats(SHR)isolated thoracic aorta and Normotensive Rats(NTR)from thechange of vasoconstriction amplitude.Results:1) Group SC compared with the Group CC, the NE reduced contraction of the vascular ringwas significantly increased.2) Compared with the Group NC, the vascular ring contraction in the group NS1 was noobvious change (P>0.05), which in the Group NS2, NS3 were reduced (P<0.05).3) Compared with the Group SC, contraction of the vascular ring in group SS1, SS2 andSS3 were reduced(P<0.05).4) Compared with the Group NS3, the vascular systolic amplitude in the Group SS3 weredecreased significantly(P<0.01).Conclusions: These results indicate that the contractile function of thoracic aorta in SHRwas increased. Sufentanil attenuated the norepinephrine-induced contraction of inisolatedthoracic aorta rings of SHR.