Pathological Change Of Intracerebral Hemorrhage In Hypertensive Patients And Effect On Prehematomal Tissues After Intracerebral Hemorrhage

Objective: To investigate the pathological changes causes intracerebral hemorrhage and influence on prehematomal brain tissues after bleeding in hypertensive patients.Methods: According to the standards of Chinese cerebrovascular disease prevention and treatment guidelines and WHO/ISH ,forty observational database of the hypertensive patients with cerebral hemorrhage from November 2009 to August 2010 in Chengdu No.2 People's Hospital were collected, including hospital records, computerized tomography(CT),operation,pathologic results,prognosis,etc. All datum are achieved by hospital records, phone call and correspondence.Used statistical methods processing data, divided the patients into two groups through the pathological result found hyaline degeneration or not and divided into two groups in accordance with found arterioles dilated change or not, and then discussed the association between hyaline degeneration or arterioles dilated change and gender, age, hypertension classification, duration of hypertension, hematoma volume, compared with didn't find hyaline degeneration groups or didn't find arterioles dilated change group. Used statistical methods to obtain meaningful results .Results: In pathological specimens slices ,we found that many arterioleshad been different degree of hyalinosis, some arterioles had occurred dilated change, and we also observed that Glial cell hyperplasia, necrosis and inflammatory cell infiltrated were appeared in some tissues around the arterioles.In respectively according to whether have found hyaline degeneration and whether have found arterioles dilated change divided groups, the ages,duration of hypertension and amount of bleeding were statistically significant difference between the groups. We found no statistically significant variables in the groups, if grouped according to other pathological types.Conclusions: Our study suggest that hyaline degeneration and dilated change are produced in arterioles of hypertensive patients'brain tissue is associated with ages,duration of hypertension and amount of bleeding. There are other meaningful results in our study: amount of bleeding is associated with GCS score on admission and outcome after 6 months; local incidence of intracerebral hemorrhage in hypertensive patients according to gender, age and position, et cetera; the effects of the managements in our department.