The Change Of CD62p On Platelet And Fibrinogen In Cerebral Infarction Patients

Objective:Platelet and fibrinogen are the main components of thrombosis. We detect the positive rate of CD62p and value of fibrinogen in cerebral infarction patients and the patients with hypertention, diabetes and hyperlipidemia(named high risk group). We explore the change of positive rate of CD62p and value of fibrinogen in deferent groups and the influence of hypertention, diabetes and hyperlipidemia on this changeMethod:The study selectes CI patients(CI group) who registered from April of 2010 to February of 2011in the department of Neurology of the first hospital in Jilin University and the healthy physical examinees (control group and high risk group) in the physical examination center in the same hospital.We chose 56 CI patients (CI group), for large size 27 patients and small size 29 patients;24 healthy examinees in control; 25 patients with hypertetion, diabetes and hyperlipidemia. The positive rate of CD62p is detected by FCM; the value of fibrinogen is detected by instrument in the labrory of the first hospital in Jilin University.Result:(1) The positive rates of CD62p in the large size CI group, the small size CI group, the high risk group and the control group are 4.21±2.12, 4.04±2.28,2.24±1.02,0.86±0.42 respectively. The levels of CD62p in CI group (large size and small size) are both higher than the control group and the high risk group (p<0.05); the level of CD62p in the high risk group is higher than healthy control group (p<0.05); the level of CD62p has no significance between the large CI group and the small CI group (p>0.05). (2) The value of fibrinogen in the large size CI group, the small size CI group, the high risk group and the healthy control group are 4.24±1.28,4.26±1.32,2.94±1.04,2.03±0.26 respectively.The level of fibrinogen in CI group (large size CI group and small size CI group) is higher than the other two groups (p<0.05);the level of fibrinogen in the high risk group is higher than the healthy control group (p<0.05); the level of fibrinogen has no significance between the large CI group and the small CI group (p>0.05)Conclusion:(1) The levels of CD62p in CI group (large size and small size) are both higher than the control group and the high risk group; the level of CD62p in the high risk group is higher than it in healthy control group; the level of CD62p has no significance between the large CI group and the small CI group. (2) The level of fibrinogen in CI group (large size CI group and small size CI group) is higher than the other two groups;the level of fibrinogen in the high risk group is higher than healthy control group; the level of fibrinogen has no significance between the large CI group and the small CI group.