The Association Study Of Hormone Sensitivity With TCM Syndromes And Signs About The Adult-onset Minimal Change Nephrotic Syndrome

ObjectiveTo summarize TCM syndromes and signs of the Adult-onset Minimal Change Nephrotic Syndrome in the treatment phase of glucocorticoid. To clarify the distribution of TCM syndromes and signs. To discuss the correlation between differences in glucocorticoid sensitivity and TCM syndromes and signsMethodsFormulate a unified observation table. Identify the glucocorticoid-sensitive of cases according to their test index. Register the symptoms and signs,tongue and pulse of cases in the observation table accurately and truthfully. Determine the TCM syndromes and signs according to uniform differentiation standards. Observe the distribution of TCM syndromes and signs of MCD. Discuss the objective laws of evolution of TCM syndromes and signs and the correlation between differences in hormone sensitivity and TCM syndromes and signs after the MCD hormone treatment.Results1.The distribution of syndromes of MCD: The distribution of deficiency in SSNS group:Qi(Yang) deficiency(50.0%)> Qi-Yin deficiency(7.0%)> Yin deficiency(5.0%), deficiency of some cases(38.0%) was not obvious. The distribution of excess in SSNS group:dampness-heat(42.0%)> stasis(20.0%)> wind-dampness(18.0%)> mixed syndromes(16.0%), excess of small proportion cases(38.0%) was not obvious. The distribution of deficiency in RNS group: Qi(Yang) deficiency(58.0%)> Yin deficiency(9.0%) or Qi-Yin deficiency(9.0%), deficiency of some cases(24.0%) was not obvious. The distribution of excess in RNS group:dampness-heat(37.0%)> mixed syndromes (24.0%)> stasis (12.0%) or stasis (12.0%), excess of some cases (15.0%) was not obvious.2. The correlation between glucocorticoid sensitivity of MCD and TCM syndromes and signs:Regarding the deficiency, the incidence of deficiency, Qi(Yang) deficiency, Yin deficiency and Qi-Yin deficiency was no significant difference (P>0.05) by comparing SSNS group with RNS one. Regarding the excess, the incidence of excess, dampness-heat and stasis was no significant difference(P<0.05) by comparing SSNS group with RNS one, and the percentage of deficiency of SSNS group was significantly greater than the one of RNS group.ConclusionThe distribution of the TCM syndromes and signs has some characteristics, in which, Qi(Yang) deficiency is common in deficiency, and wetness-heat is common in excess. Patients with glucocorticoid-sensitive MCD showed more wind-dampness, which suggests that there is some correlation between glucocorticoid sensitivity and the TCM syndromes and signs.