| Objective:To percutaneous coronary interention has become an important treatment of coronary heart disease, but the means often appear myocardial necrosis markers heighten. Postoperative increase myocardial injury markers, including predicted long-term prognosis of increased mortality rate increase rate, cardiovascular events. Previous research confirmed Chinese medicine of myocardial reperfusion injury of protection, and yiqi expectorant huoxue method in PCI perioperative have extensive application of the traditional Chinese medicine, but the influence of PCI postoperative myocardial injuries less research. This study through the observation wai PCI operation period application yiqi eliminating phlegm to invigorate the method of myocardial injury treatment, this paper discusses the influence of biomarkers of PCI postoperative myocardial protection TCM role.Methods:The study by grouping antitheses clinical research method. Follow the principle of randomized, controlled, select qualified patients 60 cases, divided into 30 cases in treatment group and 30 cases. The control group to standard heart drugs PCI, avoid with phlegm qi and promoting blood circulation; Chinese medicine The treatment group in the control group based on WenDan soup to flavored,1 pack prescription:dangshen 30g, dried tangerine or orange peel, 10g sprouting 15g, bamboo, tuckahoe 10g 15g, acid-insoluble ash 10g radha, 15g, xiong 10g, danshen, 10g pericarpium trichosanthis Xie white 10g. If the add astragalus qi difficiency peg-intron.; Yang, add the lateral; The deficiency of Yin with origin, the dwarf lilyturf; Furthermore, DanXing equal with phlegm with melon basket; Stasis peachseed, red flowers; with peg-intron. The radix and obvious. ZhiKe add, Preoperative application week, postoperative continue to applications. All cases were in preoperative and postoperative 4 hours intervention and postoperative 24 hours extraction venous blood testing CK, CK-MB, ctni. All cases were in preoperative and postoperative 1 week records symptoms and anginal attacks and according to Seattle angina scale (see the appendix) rating.Results:(1) The two groups after treatment, the treatment group significant efficiency and better than control group total effectiveness, via examining, P<0.05 greup. (2) In the treatment of myocardial injury before CKMB, cTnl CK, marker, the influence of two groups of index before treatment without significant difference compared; Each group index compared before and after treatment with significant difference (P<0.05). The two groups each index after treatment compared with significant difference (P<0.05), explain two groups in CK, CKMB, cTnl improvement, the treatment group was better than control group (3) Two groups compared before and after treatment, Seattle angina rating scores before two groups of angina treatment no significant difference; After treatment, two groups of angina pectoris total score was significant difference (P<0.05), explains that the improved angina symptoms and living quality, the treatment group than in control group. (4) The two groups after treating angina quantity, two groups compared single score greup (P<0.05).Conclusion:Modified WenDan soup can effectively relieve angina symptoms and reduce the number of angina attacks and reduce the duration of attack, increase the total effective treatment of angina pectoris and significant efficiency. PCI treatment group increased after a low incidence of myocardial enzymes, and thus speculated that Wen Dan Tang Jia Wei of PCI, has a protective effect of myocardial injury, can reduce myocardial necrosis, thereby improving myocardial perfusion, ventricular conducive to recovery. Observed no adverse effects were found during the period, suggesting that treatment of phlegm Yiqihuoxue myocardial injury after PCI is safe and effective. |
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