Remifentanil Combined With Mildhypothermia Protectscardiac Function At Early Stage Of Postresuscitafion In Rabbits

Objective To observe the effects of Remifentanil combined with mild hypothermia on postresuscitation myocardial dysfunction in rabbits, and further explore the partly underlying mechanism of action.Methods After setting up rabbit model of cardiopulmonary resuscitation,30 rabbits were randomly divided into five groups, group A:The control group, only anesthesia,surgeuy,endotracheal intubation,but not flutter, group B:Conventional CPR group; group C:in which rabbits were given hypothermia after successful ROSC; group D:in which rabbits were given Remifentanil after successful ROSC; group E:in which rabbits were given Remifentanil combined with mild hypothermia after successful ROSC. The left ventricular end-diastolic pressure(LVEDP),left ventricular pressure rise and fall rate(peak±dp/dt), serum concentrations of H-FABP and 8-iso-PGF2a were continuously observed. Result Compared with group A, LEVDP and peak±dp/dt were significantly lower/higher than in group C,D and E at 120min,120min,and 60min after complete resuscitation, respectively; however, the increase of LVEDP and decrease of peak±dp/dt in group E was minor to that in group C and there was no significant difference between group C and D. Compared with group A, H-FABP and 8-iso-PGF2ain the serum significantly increased in other four groups. H-FABP and 8-iso-PGF2ain the serum in group C, D and E were significantly lower in comparison with those in group B, furthermore, they reached a minimum in group E. Conclusions Mild hypothermia and Remifentanil can both improve postresuscitation myocardial dysfunction, and a combination of both has even stronger protective effect against brain damage, The cardioprotective effect is possible associated with the reduction of radical.