| 0bjective To explore the expression and clinical significance of cdx1,cdx2 and cdx4 gene in acute lymphocytic leukemia (ALL ).Methods Expression of CDX1, CDX2, and CDX4 was detected in 51 adult acute lymphocytic leukemia patients and 14 healthy subjects by reverse transcription polymerase chain reaction (RT-PCR). Take looks after the house the geneβ-actin to illuminate as the materials for internal reference.Results It was found that CDX1, CDX2 and CDX4 were not expressed in healthy persons and CR patients. The results showed that the positive expression rate of cdx2 gene (60.8%) in ALL patients was 60.8%, while it decreased in patients with complete remission (CR) (P < 0. 05); in relapsed patients, the expression of CDX2 (81.8%) was increased again. When the expression of CDX2 was analyzed in different risk groups of ALL patients, the incidence of CDX2 expression in high risk (HR) patients was 91.7%, and that in the standard risk (SR) group was 45.7%.Furthermore , analyses of CDX1 and CDX4 expression in our series of ALL samples did not show the expression of this ParaHox gene . In patients with adult acute lymphoblastic leukemia at diagnosis and relapse, the CR rate of patients with CDX2 positive was lower than that of patients with CDX2 negative (P < 0. 05) . CDX2 expression positive patient the median survival time must be shorter in the negative expression patient. Conclusion It was concluded that expression of CDX2 may play a synergic role in the pathogenesis of ALL and might correlate with CR rate in ALL, while the expression of CDX4 and CDX1 was not related with pathogenesis of ALL. It seemed that expression of cdx2 gene may be used as a marker of poor prognosis in adult acute lymphocytic leukemia.
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