Influence Of Severe Obstructive Sleep Apnea-hypopnea Syndrome On Auditory Function In Patients

Objective This article will investigate the effect of hypoxia,ischemia,microcirculation disturbance and micro-metabolic disorders of cochlear to the auditory system in severe OSAHS patients.Method We randomly selected 24 OSAHS patients with complete clinical data and divided them in to mild,moderate,severe group according to the severity of OSAHS disease, 8 healthy cases with no snoring symptom as control group. In acoustic cabin(noise<20 dB SPL)with sound proof,we separately detect pure tone audiometry through air conduction with normal frequencies(125～6000 Hz) and extended high frequencies(8000～16000 Hz),acoustic impedance,DPOAE,TEOAE,ABR,40Hz AERP,ASSR,and record the detection results. All the data be analyzed with SPSS 12.0 statistical software.Results 1. Air conduct hearing threshold: mild to moderate OSAHS group compared with the control group in 250 Hz and 1000 Hz normal frequencies using air conduct hearing threshold. The differences of them were statistically obvious(P<0.05). And in 500 Hz,the differences of them were statistically significant(P<0.01). Severe OSAHS group compared with the control group in 500 Hz normal frequency using air conduct hearing threshold. The differences of them were statistically significant(P<0.01). And in 16000 Hz in extended high frequencies,mild to moderate OSAHS group compared with the control group,the differences of them were statistically obvious(P<0.01). In 10000 Hz in extended high frequencies,severe OSAHS group compared with the control group,the differences of them were statistically obvious(P<0.05). 2. TEOAE detection rate: The control group compared with mild-to-moderate OSAHS group. The differences of them were statistically not obvious(P>0.05). The control group compared with severe OSAHS group,the differences of them were statistically obvious(P<0.05).3. Response amplitude of DPOAE: Mild to moderate OSAHS group compared with the control group,the differences of them were statistically not obvious(P>0.05). In 750Hz,3000Hz,4000Hz,Severe OSAHS group compared with the control group,the differences of them were statistically significant(P<0.01).4. DPOAE detection rate: In 750 Hz frequency,the DPOAE detection rate in OSAHS group is obviously declined to the control group,the differences of them were statistically significant(P<0.01). In 1000 Hz frequency,the DPOAE detection rate in OSAHS group is declined to the control group,the differences of them were statistically obvious(P<0.05).5. In ABR latencies of Wave I,Wave III,Wave V,severe OSAHS group compared with the control group,the differences of them were statistically significant(P<0.01). And in Wave IV, the differences of them were statistically obvious(P<0.05).6. 40 Hz AERP hearing threshold: Mild to moderate OSAHS group compared with the control group,severe OSAHS group compared with the control group,the differences of them were statistically not obvious(P>0.05).7. ASSR hearing threshold: Mild-to-moderate OSAHS group compared with the control group,in 500Hz,1000Hz frequencies,the differences of them were statistically significant(P<0.01),and in 2000Hz frequencies,the differences of them were statistically obvious(P<0.05). Severe OSAHS group compared with the control group in 500Hz,1000Hz,4000Hz frequencies,the differences of them were statistically significant(P<0.01).Conclusion Severe OSAHS can lead to raising of hearing threshold in conventional frequencies,extended high frequencies and ASSR,and also result in declining of OAE detection rate and response amplitude of DPOAE,prolong the latencies of ABR wave. OSAHS can bring about the injury of cochlear function.