The Clinical Research On The Relationship Between Blood Urea Level, BNP And Cardiac Function

The highest mortality after coronary heart disease to cancer diseases, through myocardial ischemia, myocardial infarction, myocardial fibrosis, secondary to cardiac dysfunction caused by cardiac arrhythmias, the development of heart failure. Heart failure markers and risk factors of heart failure benefit for risk of coronary heart disease group, early diagnosis, early treatment and to observe the efficacy, thereby reducing the incidence of coronary heart disease and mortality in heart failure. Abundant in the ventricular expression of BNP in cardiac hypertrophy and in heart failure, its upregulation of serum BNP in patients with chronic heart failure may be increased more than ten times, which is a valuable diagnostic tool for heart failure.The previous population studies and animal experiments through the study found that UT-B gene mutation, UT-B protein deficiency, the blood urea levels were significantly increased, which can induce progressive familial occurrence of cardiac conduction delay and left ventricular hypertrophy and cardiac dysfunction.Objective:In previous work, based on the clinical heart failure patients for the study to analyze their blood BUN and BNP to cardiac hypertrophy and heart functional relevance, is proposed for the exploration of new markers of coronary heart disease and risk factors of heart failure to provide theoretical basis. To prevent the development of coronary heart disease in cardiac hypertrophy and heart failure provide a theoretical basis.Methods:From hospital from January 2008 to January 2010 patients hospitalized with coronary heart disease, detection of serum BNP levels, blood urea nitrogen (BUN), creatinine level, Doppler echocardiographic measurement of ejection fraction EF, fractional shortening FS, left ventricular diastolic diameter, left ventricular posterior wall thickness. Select the creatinine clearance rate is normal (neither renal dysfunction) were 266 cases of the research object, for statistical analysis.In accordance with the urea nitrogen<8.31mmol/L and blood urea nitrogen> 8.31mmol/L to group, using t test analysis of plasma BNP levels, blood urea nitrogen, left ventricular hypertrophy and cardiac function between the correlation.Because the distribution of serum concentrations of BNP is not a non-normal distribution, linear regression analysis, making use of log BNP value, Pearson linear regression analysis to analyze the serum BNP levels and LVEF, LVFS, age, left ventricular diastolic diameter, left ventricular posterior wall thickness correlation between.Results:l,The T test and X2 test statistical analysis of the basic experimental and clinical data of the control group to compare the age, gender, etc. without significant differences between the two groups (P> 0.05);2, Met the inclusion criteria of cases there were 266 cases detected in patients with coronary heart disease standard BNP (6362.2±623.8 pg/ml) and normal control group (179.1±88.24 pg/ml) were compared, results showed that plasma BNP levels in patients with significant coronary artery disease control group, significant differences (p<0.01);3,Serum log BNP values in patients with coronary heart disease change and LVEF (r =-0.65), LVFS (r=-0.66) negatively correlated with left ventricular diastolic diameter (r= 0.489), left ventricular posterior wall thickness (r= 0.271) positive correlation;4, Blood urea levels in patients with coronary heart disease increased, BUN> 8.31mmol/L serum BNP levels (9146.7±1438.7 pg/ml) was significantly higher than BUN<8.31 mmol/L group (1995.7±266.5 pg/ml), left ventricular posterior wall thickness (11.3±0.28 vs 10.3±0.17mm) and left ventricular end diastolic diameter (59.85±1.17 vs 52.74±0.81 mm) was significantly higher than that of BNP<8.31 mmol/L group (P<0.01), on behalf of the parameters of cardiac function EF (0.44±0.018 vs 0.59±0.011), FS (0.21±0.009 vs 0.27±0.006) was significantly lower than the BNP<8.31mmol/L group (P<0.01).Conclusion1, Plasma BNP levels in patients with coronary heart disease was significantly higher than the normal control group2, Serum log BNP values in patients with coronary heart disease change and LVEF, LVFS negatively correlated with left ventricular diastolic diameter, left ventricular posterior wall thickness correlated; prompt diagnosis BNP can be used as biomarkers of coronary heart failure, there is a certain sensitivity and specificity.3, Elevated levels of blood urea, BUN> 8.31mmol/L serum BNP levels were significantly higher in patients with BNP<8.31 mmol/L group, left ventricular posterior wall thickness and left ventricular end diastolic diameter was significantly higher than that of BNP<8.31 mmol/L group (P<0.01), the parameters of cardiac function on behalf of EF, FS was significantly lower than the BNP<8.31mmol/L group (P<0.01). Tip of urea may be used as reflecting cardiac function in heart failure and ventricular size indicators. And may lead to decreased heart function in patients with one of the reasons.