| Backgrounds and objections:Coronary disease for many kinds of factor functions in the different link result, these is coronary disease's hazard factor, including the age, the sex, smoking, the blood fats exceptionally, the blood pressure elevates, diabetes and the sugar tolerance exceptionally, bilirubin, uric acid, fibrinogen and so on, beforehand six items for primary hazard factor. And the age, the sex, smoking, the blood fats exceptionally, the blood pressure elevates obtained doctor and the patient widely takes seriously, but the cardiovascular dangerous event's disease incidence rate still continued to elevate the tendency, therefore the prevention which gets sick regarding coronary disease and other cardiovascular illness still needed the general medical officers to give takes seriously, Already was clear about diabetes for coronary disease's independence hazard factor, but considered diabetes are chronic expansibility disease, therefore in its disease's developing process, if gives certain intervention, may reduce coronary disease, diabetes'disease incidence rate greatly,and the recent years, some research indicated that the blood serum glucose level occurs regarding the cardiovascular disease's damage early.Therefor this article exceptionally conducts the research to the sugar tolerance with the coronary disease hazard factor, but the bilirubin and the blood uric acid still had the dispute as coronary disease's hazard factor, in the article carries on the research contrast to it with the crown arteries integral's between data, thus provides a new platform for coronary disease's prevention.Method:Chooses Jilin University China and Japan to get together the hospital in June,2009 to September,2010 period in hospital patient, the being selected object of study is and/or the electrocardiogram performance characteristic admits in hospital according to patient's clinical manifestation by coronary disease. (1999) (1997) diabetes'diagnosis standard will be selected according to WHO with the American Diabetes Academic society coronary disease patient to divide into:(1), coronary disease merge sugar tolerance normal group (NGT group):Altogether 45 examples (male 23 examples, female 22 examples), age 40-68 (57.6±9.8) year old; (2), coronary disease merge sugar tolerance unusual group (IGT group):Altogether 40 examples (male 24 examples, female 16 examples), age 38-65 (57.6±8.9) year old; (3), coronary disease merges 2 diabetes groups (the DM group):Altogether 47 examples (male 28 examples, female 19 examples), age 42-70 (59.6±9.6) year old. All patients after in hospital the next morning empty stomach 12 small fashionable OGTT experiments, simultaneously examine the blood fats, the hepatorenal function, the electrolyte, the uric acid, the bilirubin and so on. And the detailed inquiry medical history, the computation body weight index, the record sex, the age come of age the arteries index. Using the T-test, the card side examination, the straight line correlation analysis and the multiple regression analysis carry on processing to the data.Results:1. During three groups of ages, body weight index, TG, TC, LDL-C, HDL-C baseline level non-statistics difference (P>0.05).2. The uric acid level during three groups of comparisons, three group of uric acid horizontal overall tendency is elevates gradually from the NGT group to the DM group, the DM group and the IGT group obviously are higher than the NGT group, IGT group and DM group not remarkable statistics significance (P>0.05).3. The bilirubin level three groups of comparisons, three group of bilirubin horizontal overall tendency is reduces gradually from the NGT group to the DM group, the NGT group is higher than the DM group and the IGT group obviously, the DM group and the IGT group does not have the obvious statistics significance (P>0.05).4. Gensini grading result and group comparison:The Gensini grading assumes from the NGT group to the DM group overall tendency advances in echelon obviously, the neighboring two groups of differences have the extremely remarkable statistics significance (p<0.01).5. In the regression analysis, the coronary artery pathological change degree (take the Gensini integral as standard) with 2hPG, the uric acid, the low density lipoprotein, the total cholesterol assumes is remarkable is being related, assumes the inverse correlation with the bilirubin.Conclusion:1. The coronary disease merge sugar tolerance unusual patient's coronary arteriosclerosis pathological change's order of severity obviously is higher than the blood sugar normal patient, close diabetic.2. The sugar metabolic anomalies and the blood uric acid elevates, the total bilirubin to reduce has certain synergism, three coexist makes the coronary artery pathological change degree to further aggravate.3. Coronary disease patient meal the latter 2 hours blood sugars and the coronary artery pathological change order of severity present is related. |
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