Research By 1HMRS Given Phenobarbital After Traumatic Brain Injury On Brain Metabolism

[Objective] To observe the changes in brain metabolites that given phenobarbital therapy in TBI (traumatic brain injury) patients by 1H magnetic resonance spectroscopy (1H MRS) and to assess the prognosis after brain injury.[Methods] Admitted to our hospital 2009.3-2010.9 met the study inclusion criteria diagnosed 24 cases of brain injury after emergency surgery patients were randomly divided into phenobarbital group and the control group that the control group underwent conventional treatment, phenobarbital group were given after 6 hours of operation,start measuring the load more than 30 minutes 10mg/kg,5mg/kgx3 hours, to maintain measurement 1mg/kg.h, continuous application of 1 week. Phenobarbital group and control group after 6 days using 1H magnetic resonance spectroscopy, respectively, frontal brain, basal ganglia, and occipital N2 acetyl aspartate (NAA), lactate (Lac), creatine (Cr), choline containing compounds (Cho) and NAA/Cr, NAA/Cho, Cho/Cr values change, and statistical analysis of the indicators.[Results] line 1HMRS examination showed phenobarbital group than in the control group, NAA/Cr and Cho/Cr differences were statistically significant, patients with frontal and occipital lobes and basal ganglia area NAA/Cr, NAA/Cho values in which significantly,decreased compared with normal control group, Cho/Cr values higher than normal control group, while basal ganglia NAA/Cr the highest, followed by occipital, Cho/Cr compared with other high-occipital lobe. GOS grading outcomes after 6 months of phenobarbital group showed no statistical significance with the control group.[conclusion] The phenobarbital may change the brain metabolite change, has the influential role to the patient course of treatment, but to prognosis non-statistics significance. Through 1HMRS may understand that in brain zones of different metabolism change, simultaneously to appraises the prognosis to have the important value.