The Clinical Research On Efficacy And Influence To IL-8 Of Acute Exacerbations Of Chronic Obstructive Pulmonary Disease With Phlegm And Heat Syndrome With The Management Of The Fu Leaks A Hot Method

ObjectiveThe aim of the study was to assess the clinical effect and the influence and meanings to IL-8 of the Fu leaks a hot method to chronic obstuctive pulmonary disease in acute exacerbation.The other aim of the study was to study the clinical research and the mechanism of cure of the lung and the large intestine being interior-exteriorly related.Method60 patients AECOPD according to the retention of Obstruction of Lung by Phlegm and heat syndrome in TCM were selected from the outpatient clinic. Patients were randomly assigned to the treating group(group T)or to the control group(group C)on a single—blind basis. Group T was treated by routine westem medicine combination with The Fu leaks a hot method for 7days and group C was treated by routine westem medicine combination with the management of clear away heat and disperse phlegm. Comparing the clinical symptom, IL-8, blood gas analysis of the patients with mild or moderate COPD in acute exacerbation condition according to the Obstruction of Lung by Phlegm and heat syndrome in TCM.Result 1. The total effective rate of the therapeutic group and the control group were 96.7% and 70% respectively, The clinical symptoms and sign of the treating group have significant difference (p<0.05) after 7days comparing with the pre-treatment which showed the management of the treating group could improve the clinical symptoms and sign of AECOPD patients. Compared with the pre-treatment, the control group have significant difference (p<0.01)in some symptoms and signs, such as cough, sputum, gasp, fever, abdominal distention, constipation, souchi, chest distress, rhonchus. It showed that the therapy of control group also could improve some of the clinical symptoms and sign of COPD patients. The clinical symptoms and sign of the treating group have significant difference (p<0.01)after 7days comparing with the control group except for cough, sputum, rhonchus, chest distress. Main syndrome had been improved significantly in group T(P<0.01)which has significant difference compared with group C(P<0.01)2. As for the result of blood gas analysis, group T and group C could both improve the PO2 and reduce the PCO2. And there was significant difference in group T compared with group C(P<0.01)about anoxia and carbon dioxide retention,3. According to IL—8, there was significant difference in two group(P<0.01). There was significant difference compared group T with groupC after treatment(P<0.01). It showed that the therapy of group T and group C could improve signs and symptoms of Airway Inflammation of AECOPD, in which it would be involved in the decrease of IL-8 level in mechanism. And there was significant difference in group T compared with group C(P<0.01).ConclusionTake the chinese medicine theory of "the lung and the large intestine being interior-exteriorly related" as instruction, routine westem medicine combination with the Fu leaks a hot method reduced syndrome,improved anoxia and carbon dioxide retention and debased the level of IL-8 relative to group C(by routine westem medicine combination with the management of clear away heat and disperse phlegm) in clinical trials on patients with AECOPD by Phlegm and heat syndrome in TCM.