Correlation Between Indexes Of Arterial Elasticity Function On Different Sites Of Arterial System And Renal Function In Essential Hypertensive Patients

Objective: To study the correlation and impact factors of pulse wave velocity (PWV) with C1, C2, ABI in hypertensive patients.Methods: 140 subjects [38 normotensive subjects (NS group) and 102 essential hypertensive patients (EH group)] were enrolled. Different segments of PWV (baPWV, cfPWV, cbPWV, faPWV) and ABI were measured by BP-203RPE II (VP-1000) device. C1, C2 were measured by CVProfilor DO-2020 device. The correlation between cfPWV and other indexes of arterial elasticity function was analyzed.Results: (1) Each segment of PWV and ABI were significantly higher in EH group than that in NS group (P<0.01). C1, C2 were significantly lower in EH group than that in NS group (P<0.05). (2) Other segments of PWV correlated positively with cfPWV (P<0.01), while cbPWV and baPWV showed the best correlation with cfPWV (r=0.792 and 0.703, P<0.01). C1, C2 correlated negatively with cfPWV (P<0.01). ABI correlated positively with cfPWV (P<0.05). (3) Age and blood pressure were the mutual impact factors of arterial elasticity function indexes. With progressing aging (every 10 years), the risks of increasing cfPWV, baPWV, cbPWV and faPWV were raised by 180.3%, 347.4%, 131.3%, 69.0%, and the risks of decreasing C1 and C2 were raised by 116.0%, 219.6%. The risks of increasing cfPWV, baPWV and faPWV were raised by 141.3%, 218.8%, 50.9%, and the risks of decreasing C2 and C2 were raised by 169.3%, 67.9% along with every 10 mmHg SBP elevating. The risks of increasing cbPWV and ABI were raised by 124.6% and 37.8% together with every 5 mmHg DBP elevating.Conclusions: baPWV is a simple and relatively sensitive method of measuring PWV. Age, SBP and DBP are the mutual risk factors of the elevated stiffness in both central and peripheral artery.Objective: To study the correlation between renal function (GFR and mAlb) and arterial elasticity function (baPWV, cfPWV, C1, C2 and ABI) in hypertensive patients.Methods: 140 subjects [38 normotensive subjects (NS group) and 102 essential hypertensive patients (EH group)] were enrolled. baPWV, cfPWV and ABI were measured by BP-203RPE II (VP-1000) device, and C1, C2 were measured by CVProfilor DO-2020 device. Glomerular filtration rate (GFR) and microalbuminuria (mAlb) were used as the indexes of renal function.Results: (1) baPWV, cfPWV and ABI were significantly higher in EH group than that in NS group. C1, C2 and GFR were significantly lower in EH group than that in NS group. (2) baPWV and cfPWV increased progressively with decreasing GFR (P<0.05), but C1, C2 and ABI had insignificantly change with decreasing GFR. With increasing mAlb, no significant difference was found in all indexes of arterial elasticity function. (3) There was a significant and negative correlation between PWV and GFR. baPWV showed the best correlation with GFR (r=-0.405,P<0.01). C2 correlated positively with GFR (P<0.05). No correlation was found between mAlb and all indexes of arterial elasticity function. Adjusting for age and blood pressure, even significant association between all indexes of arterial elasticity function and GFR was disappear.Conclusions: The association between arterial stiffness and GFR in essential hypertensive patients was largely depended by their associated risk factors, such as age and blood pressure. Arterial stiffness correlated insignificantly with mAlb.