| Objective:To explore the effect of emotional cognitive function.of EA combined with repetitive transcranial magnetic stimulation (rTMS) on CAD patients.Methods:Ninety cases of CAD were randomized into three groups.30cases in observation group were treated with electroacupuncture combined with rTMS(EA group).30 cases in control group were treated with simple rTMS. another 30 cases in control grop were treated with simple pharmacotherapy.and another 30 nomal cases as normal control. Separately, before treatment,5 days and 10 days after treatment, Hemilton Depression Scale (HAMD) and Hemilton Anxiety Scale (HAMA) were used for the scoring of depression and anxiety. Additionally, the efficacies were compared through three groups.90 CAD cases and 30 health volunteers were recruited Event related potentials(ERP),such as P300,MMN,P50,CNV,were applied to recorder the change of emotional cognition before and 10 days after treatment.Results:1.5 days and 10 days after treatment, HAMD and HAMA score in EA group was lower than that in rTMS group and medicine group (P<0.001). and 5 days after treatment, rTMS group was lower than that in medicine group.10 days after treatment HAMD score in rTMS group was lower than that in medicine group.2.The remarkable effective rates of depression and anxiety in EA group 5 days after treatment were 56.7%(17/30) and 66.7%(20/30) respectively, which were higher apparently than 30%(9/30) and 26.7%(8/30) in rTMS group,and higher than 11.1% (3/27) and 11.1%(3/27) in medicine group separately (P<0.05). The remarkable effective rates of depression and anxiety in EA group 10 days after treatment were 90%(27/30) respectively, which were higher apparently than 63.3%(19/30) in rTMS group,and higher than 57.9%(14/27) in medicine group separately (P<0.05).3.the MMN latency in EA group before treatment was longer than that normal group (P<0.05),but the difference from the nomal group disappeared after treatment (P> 0.05). there was significant difference between before treatment and after treantment in EA group. (P<0.001). MMN latency in rTMS group was lower than that normal group (P<0.05). MMN latency in medicine group before and after treatment was longer than that normal group (P<0.05),and no significant difference between before and after treatment (P>0.05). MMN latency in EA group after treatment was lower than that normal group and rTMS group (P<0.05).the amplitude in each group before and after treatment has no significant difference (P>0.05).4. N1 latency in EA group before treatment was longer than that after treatment (P<0.05),there was no significant difference between rTMS group and medicine group before and after treatment (P> 0.05). there was no significant difference between each groups before and after treatment (P> 0.05); the P3a, P3b latency of the three groups before treatment was longer than the normal group (P<0.001), but the difference from the nomal group disappeared after treatment (P> 0.05). There were no significant difference in both rTMS group and medicine group before and after treatment, and the latency of both groups after treatment still much longer than that in normal group (P<0.05). the latency in EA group was shorter than that in both rTMS and medicine groups after treatment (P<0.05). the amplitudes of P3a,P3b,N2-P3b in medicine group before treatment were remarkably different from that of normal group (P<0.05). the amplitude of N1,P2,N2 in the foure groups have no obvious difference in interior-group and enter-group (P>0.05) 5. A point latency of CNV before treatment of EA group were longer than that after treatment (P<0.05), and the result after treatment significantly differed from that of medicine group after treatment (P<0.05). the rate of PINV of EA and medicine groups before treatment were lower than that in normal group (P<0.05), but the difference extinguished after treatment (P> 0.05). A-B amplitude in each group have no obvious difference in interior-group and inter-group (P> 0.05).6. The P50 amplitude of three groups before treatment were higher than that in normal group (P<0.05), and there were no difference in interior-group of the three before and after treatment (P> 0.05).Conclusion:firstly, The integrative therapy of electroacupuncture and rTMS was definitely effective on CAD, and is considered as an effective approach to CAD, and the symptoms are improved time-dependentiy.Secondly,EA combined with rTMS could improve the CAD patients emotions and impaired cognitive function in different degrees.Thirdly,EAcombined with rTMS could improve the CAD patients with Short-term memory and attention.Last, EA combined with rTMS could significantly improve patients with automatic recognition of early cortical process of information. |
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