Influence Of Rocuronium On Bispectral Index During Different Effect-site Concentration Of Propofol

Objective To investigate whether rocuronium can affect bispcetral index during different effect-site concentration of propofol .Methods Sixty ASAâ… orâ…¡p atients undergoing elective surgery were enrollded in the study,based on Ce of propofol,the patients randomly divided into four groups (R2and R3)and(C₂ and C₃)(n = 15).When the Ce of propofol reached 4.0μg/ml and OAA/S score was below one,a laryngeal mask airway was inserted,Ce was then maintained at 2.0μg/ml or 3.0μg/ml for 20min.Rocuronium 2ED₉₅0. 6 mg/kg was gived in groups R2and R3, normal saline(5ml) was gived in the other two groups . BIS,HR and MAP values were recorded before induction of propofol immediately(T₁),injection rocuronium or normal saline immediately(T₂),TOF reached 0(T₃), The first TOF twitch of muscle recovered to 5 % (T₄).Results There was no significant difference in sex, age, body weight among four groups. There was no significant difference in BIS between groups C₂ and C₃ whenT₁-T₄.The BIS of T₃ and T₄ were significantly lower than T₂ in group R2 but not in group R₃, C₂ and C₃.Compared with the same Ce,there was no significant difference between group R₂,C₂ and group R₃,C₃.Conclusion Rocuronium alters the BIS scores in moderately sedated patients but not in deeply sedated patients,the scores of BIS were decreased after a bolus 2 times ED₉₅ of rocuronium when Ce of propofol set at2. 0μg/ml ,but Ce of propofol set at3. 0μg/ml,there were no change in BIS scores.