The Resting-state FMRI Study Of Secondary Generalized Epilepsy

Object To explore the functional network and study the underlying neuro-pathophysiological mechanism of the secondary generalize epilepsy (SGE) by BOLD-fMRI.Method 31 patients with SGE and 30 gender, age and education-matched healthy controls were performed resting-state BOLD-fMRI scan. Brain function was investigated by amplitude of low-frequency fluctuation(ALFF) and functional connectivity(FC) analysis in both two groups.Result 31 patients with SGE and 30 healthy controls finished the MRI scan. After excluding 6 data because of head movement,26 patients and 29 healthy controls' data was finally analyzed.1. ALFF analysis: Compared with controls, SGE patients showed significantly increased ALFF in left inferior temporal gyrus, left parahippocampal gyrus, left corpus callosum, left precentral gyrus, left parietal and right frontal lobe; regions whose ALFF decreased include:right lingual gyrus, left cuneus, right middle occipital gyrus and right precuneus.2. FC was calculated with ROI of the precentral gyrus. Patients with SGE showed significantly increased functional connectivity in right middle frontal gyrus and decreased functional connectivity in right precuneus.Conclusion 1.The resting-state fMRI study showed widely dysfunction network in SGE group.2.ALFF has the ability to detect epileptic activity 3.The abnormal of middle frontal gyrus and precuneus may be most important pathology basis in SGE.