Clinical Study Of Sexual Dysfunction In Male Patients With Pituitary Adenomas

Objective:To discuss the clinical feature and related factors of sexual dysfunction in the male patients with pituitary adenomas.Methods:We reviewed medical records of 86 male patients with pituitary adenomas and collected questionnaires about sexual function retrospectively, then analyzed the correlations between sexual behavior and age, tumor type, invasion, tumor size, serum prolactin, serum testosterone.Results:69(80.2%) and 3(37.5%) sexual dysfunction were found in 78 patients with functioning pituitary adenomas and in 8 patients with Non-functioning pituitary adenomas, respectively. In the functioning pituitary adenomas groups, the incidence of erectile dysfunction and reduced sexual desire and ejaculation dysfunction was 92.1%(35/38) and 84.2%(32/38) and 76.3%(29/38) in PRL group, respectively. In the FSH group, the incidence of erectile dysfunction and reduced sexual desire and ejaculation dysfunction was 69.7%(16/23) and 78.3%(18/23) and 65.2%(15/23), respectively. In the GH group, the incidence of erectile dysfunction and reduced sexual desire and ejaculation dysfunction was 70.6%(12/17) and 52.9%(9/17) and 41.2%(7/17), respectively.Conclusions The incidence of sexual dysfunction in the males with functioning pituitary adenomas was higher than in the males with Non-functioning pituitary adenomas. In the functioning pituitary adenoma groups, erectile dysfunction was the most important symptom in PRL group and the incidence, either reduced sexual desire or ejaculation dysfunction, in GH group was lower than in PRL group and FSH group. Pathology of the pituitary tumors was the main risk factor to result in sexual dysfunction.