Preliminary Research On The Different Cytogetic MDS's Biological Characteristics

Objiective:This study was aimed to investigate the biological characteristics of MDS which were classified by cytogenetics. The biological characteristics came from peripheral blood cell count, bone marrow cytology and the treatment of Qinghuang power.Methods:We adopted the way of retrospective study and the clinical data, laboratory, chromosomal information of 211 cases of MDS in recent 5 years were collected. The data were analyzed by SPSS 17.0 software.Results:(1) Cytogenetic characteristics:98 (46.44%) out of 211 cases had clonal chromosome aberrations.Among these chromosome aberrations, the number and incidence of+8, complex karyotype,20q-and-Y,7 chromosome abnormality, 5q-and other chromosome aberrations is:33 (15.64%),15 (7.11%),6 (2.8%),5 (2.37%),4 (1.90%),4 (1.90%),31 (14.69%).(2) Characteristics of the different Cytogenetic MDS's peripheral blood:there were 135 patients which had early peripheral blood cell count materials. These patients were classified into five groups, they were normal karyotype group, +8 group, complex group,20q-group,other karyotype group. We analyse WBC, Hb, and PLT respectively in these groups and there were no statistically significant results in these five groups (P value 0.415,0.224,0.616).(3) Characteristics of the different Cytogenetic MDS's bone marrow cytology:There were 123 patients which had early myeloproliferative degree materials.These patients were classified into five groups(normal karyotype group,+8 group, complex group,20q-group,other karyotype group)and there was no statistically significant result in these five groups(P value 0.415);There were 131 patients which had early bone marrow primitive cell count materials. These patients were classified into five groups(normal karyotype group,+8 group, complex group, 20q-group,other karyotype group) and there was no statistically significant result in these five groups (P value 0.454);There were 77 cases of patients with eary bone marrow morphology materials.They were divided into two groups(normal karyotype group and abnormal karyotype group),The abnormal karyotype group didn't have more chances of having granulocyte morbid hematopoiesis(P=0.558),but the results were opposite in erythroid and megakaryocytes'dysplasia(P value 0.045,0.028).(4) Characteristics of the different Cytogenetic MDS's reactions to Qing huang power:there were 108 patients who received treatment for 3 months. The respective number and proportion of the powerful (CR+PR+HI),stable, the invalid is 44 (41.51%),53(50%),9 (8.49%).These patients were classified into four groups(normal karyotype group,+8 group, complex group, other karyotype group) and there was no statistically significant result in these four groups (P value 0.493);there were 88 patients who received treatment for 6 months. The respective number and proportion of the powerful (CR+PR+HI),stable, the invalid is 49 (55.68%),35(39.77%),4(4.53%).According cytogenetics,these patients were classified into four groups(normal karyotype group,+8 group, complex karyotype group, other karyotype group)and there was no statistically significant result in these four groups (P value 0.275).(5) Impact of Qinghuang power on the Course of Myelodysplasia with complex karyotype:we visted 14 patients with complex karyotype.There were 7 inpatients and 7 outpatients.Among these outpatients, no patients died during the 5-44 months and the median surial was not reached. However,the 7 inpatients'median surial was 12 months. And there was statistically significant result between two groups(P=0.019).Conclusion:The different Cytogenetic MDS didn't have characteristics in peripheral blood and reactions to Qing huang power,but Qinghuang Power perhaps could improve MDS'S natural progression. In terms of bone marrow cytology, the different Cytogenetic MDS didn't have characteristics in myeloproliferative degree, bone marrow primitive cell count and granulocyte morbid hematopoiesis, but the results were opposite in erythroid and megakaryocytes'dysplasia.