The Study On The Relationship Between Levels Of Serum Cystatin C And Cerebral Infarction And On The Influential Factors Of Cystatin C

Objectives: to observe the changes of serum Cystatin C in patients with cerebral infarction and investigate its clinical significance. many researches considered Cystatin C was related with cerebrovascular disease, and it was a causative factor of Alzheimer disease and brain hemorrhage, some overseas researches considered Cystatin C was a protective factor to asymptomatic cerebral infarction. The disease rate and mutilation rate of clinical cerebral infarction are very high, the aim of this study is to investigate the relationship of Cystatin C and cerebral infarction, evaluate the application value of Cystatin C in condition and course of cerebral infarction, so as to give clinical intervention.Objects and Methods: from January to October in 2007, 84 cerebral infarction in patients diagnosed through CT and (or) MRI were selected, include 46 male and 38 female cases, at the corresponding time period, 76 subjects accepted health examination were selected as control group, include 33 male and 43 female cases. To fill in questionnaires by the method of face to face questionnaire and look up the illness records, collected the general state of health and correlated information of all cases. At the same time, to draw blood 3ml from each person of the two groups, to separate serum, preserved in -20℃refrigerator and determine samples when collection was over. This experiment was carried out in HIV-Ab laboratory, used END POINT instrument, reagents were supplied by Shang-hai De-bo biology technology limited company, samples were determined by method of euzymelinked immunosorbent assay, wavelength was 490nm. To arrange the data and input in computer, establish table by Excel 2003, adopt package SPSS(11.5)to carry out statistical analysis. All data were indicated by mean±standard deviation, measurement data were analyzed by T test, numeration data were analyzed byχ2 test or F test, cerebral infarction and each risk factor were analyzed by multiple factor Logistic regression analysis, the relation of cerebral infarction and other variables were analyzed by multivariant gradual regressive analysis.Result: 1. serum Cystatin C is significantly lower in cerebral infarction group(1.69360±0.603101) compared with control group(2.00619±0.679114), there was statistical significance between the two group(P=0.002<0.05). 2. the level of serum Cystatin C in female objects was higher than male objects, but there was no statistical significance between them(P>0.05).There was no associativity between gender and serum Cystatin C(r=0.004, P=0.96>0.05).3. There was positive correlation between age and serum Cystatin C(r=0.206, P=0.009<0.05).Conclusion:1. Cystain C is possible related to cerebral infarction, Cystain C is a possible infuluential factor to clinical cerebral infarction. 2. There is a positive correlation between age and serum Cystatin C, the level of serum Cystatin C rises along with age. 3. There is no correlation between gender and Cystatin C.