Diagnosis Of Liver Tumors And Evaluation Of Arterio-venous Fistula Of Primary Hepatocellular Carcinoma By Using Contrast-enhanced Ultrasound

Part One:The Contrast-enhanced Ultrasound Assessment of Liver Tumors Using quantitative analysis Objective To analyze the quantitative analysis of contrast-enhanced ultrasound (CEUS) in liver tumors diagnosis.Methods 92 patients with 102 focal liver lesions,including 59 malignant and 43 benign,were examined carefully after injected contrast agent(Sono Vue).The CEUS features were studied,including enhancement patterns,arrival time of contrast agent,enhancement phases, wash-out time and time-intensity curve(TIC) for enhancement peak time .Deal those factors with multi-factor logistic regression analysis and some significant factors using statistical analysis.Results Most of 59 liver malignant tumor contrast agent arrived less than 20 second in early arterial phase, and peak time less than 32 second. Compared with benign lesions, the differences have statistical significance.Conclusions The enhancement in early arterial phase of liver tumor is have clinical diagnosed value to characterization,combined with other factors improving diagnosed ability for 1iver malignant 1esion. Part Two: Evaluated Tumor Differentiation and Arterio-venous Fistula of Primary Hepatocellular Carcinoma with Contrast- enhanced UltrasoundObjective To evaluate the relationship between enhancement pattern of primary hepatocellular carcinoma(PHC) and tumor differentiation. According to digital subtraction angiography, exploring the apperances of arterio-venous fistula by using contrast-enhanced ultrasound.Methods To retrospectively analyze enhancement pattern of 65 patients with PHC in Tongji Hospital form Juy,2007 to Sept,2009. There are 44 cases in three groups according to pathologic grading of hepatocellular carcinoma(HCC). The perfusion of lesions were analyzed . Recording arrival time, wash-out time, wash-out pattern,et al and using statistical analysis. According to digital subtraction angiography, the apperances of arterio-venous fistula were analyzed by using contrast-enhanced ultrasound.Results No significant differeces were foune between pathology differentiation and enhancement pattern of CEUS. The PHC lesions washing out quickly have arterio-venous fistula more frequently.Conclusions CEUS can demonstrate the perfusion and arterio-venous fistula of tumor lesions,thus having important value in treating primary hepatocellular carcinoma.