| Objective To explore the changes of serum heme oxygenase-1(HO-1) and placental growth factor(PLGF) , This may help us understand the pathophysiology of polycythemia and chronic mountain sickness(CMS),also provide the basis for preventive and treatment.Methods The serum levels of PLGF and HO-1 in 18 healthy adults (control group), 16 CMS patients(CMS group) were determined by quantitative sandwich enzyme immunoassay. Meanwhile, The levels of Hb,Hct and SaO2 were determined. Results The serum levels of PLGF [(45.98±22.11) pg/ml]; HO-1 [(8.12±3.42) ng/L] in CMS were significantly higher than these in the control group [(20.98±3.34) pg/ml];[(3.00±0.63)ng/L],they have significant difference (P<0.001);Hb concentration was positively related with serum level of HO-1,PLGF in CMS patients (P< 0.001); SaO2 was negatively correlated with serum level of HO-1 and PLGF in CMS patients (P<0.001). and there were positively correlated between HO-1 and PLGF (P< 0.001).Conclusions The results of this study showed that there were over expressions of serum HO-1 and PLGF in patients with CMS. It suggests that HO-1 and PLGF may play a crucial role in generation and progression of CMS through of contributing to the angiogenesis and the erythrocyte proliferation. |
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