Study On The Relationship Of Serum Hs-crp,oxidativestress In Acute Atherosclerotic Cerebral Infarction

Objective: By measuring the composition of serum sensitivity C-reactive protein(hs-CRP) in actue atherosclerotic cerebral infarction,we try to explore the relationship of hs-CRP with the atherosclertic plaque and the meaning in cerebral infarction.In addition, the serum malondialdehyde (MDA),superoxide dismutase(SOD) and nitric oxide(NO) were meansured,also, the relationship between hs-CRP and oxidative damage and the connection between hs-CRP and acute cerebral infarction were studyed.Methods: 1.We collected 83 cases of carotid artery atherosclerotic infarction patients and 25 healthy controls ,which were compared between the serum hs-CRP, lipid levels, MDA, SOD, NO levels. 2. According to the results of the bilateral carotid ultrasonography examination we divided into soft plaque, hard plaque group, no plaque group(three sub-groups), and comparesed these serological markers in the cerebral infarction cases . 3.According to MRI infarction size ,we assigned infarction patients into three groupâ‘ the large infarction group: more than one lobe, 50mm or more.â‘¡the menium infarction group: less than one lobe, 31 ~ 50mm.â‘¢the small infarction group: 16 ~ 30mm.to comparethe serun markers and plaque stability of patient with different cerebral infactional size .Results: 1,There are some significant differences between the cerebral infarction and the control group.The levels of hs-CRP, TC, GLU, MDA, SOD and NO (P <0.05)were higher in the cerebral infarction.2,On the basis of the area of substantial damage to brain MRI ,we assigned into three sub-groups, which showed the greater infarct area was, the measured value of the hs-CRP, MDA, NO, LDL, and NIHSS was higher, while the lower level of SOD.3,According to the plaque stability ,we compared the value of three groups of patients with cerebral infarction between hs-CRP, MDA, NO, SOD, LDL, NIHSS, finding that the result was statistically significant (P <0.05 );4.The correletion analysis showed that :The hs-CRP was positively correlated with MDA ,negatively correlated with the SOD.After congtroling the infarction size ,we got the same result. hs-CRP and plaque levels were positively related to rank. the more hs -CRP increased ,the unstable the plaque was. After controling the factors of cerebral infarction area and oxidative stress ,there are still significant in above markers.(P <0.05)Conclusion:â‘ hs-CRP reflects the carotid atherosclerotic plaque stability in serum markers, may be an indicator of acute carotid atherosclerotic cerebral infarction.â‘¡The higher the severity of cerebral infarction is, the more serious the oxygen free radicals and lipid peroxidatic stress are.Meanwhile,the hs-CRP levels was significantly increased, suggesting that hs-CRP may be associated with oxidative stress, involved in oxidative stress after ischemia and reperfusion injury process.