The Effects Of Atorvastatin On Left Atrial Structure And Fucntion In Patients With Atrial Fibrillation After Radiofrequency Catheter Ablation

Objectives1.To observe the changes of left atrial structure and fucntion in patients underwent circumferential pulmonary vein ablation plus left atrial linear ablation using echocardiogram.2.To investigate the effects of atorvastatin on left atrial fucntion and structure in patients with atrial fibrillation using echocardiogram.MethodsWe enrolled 24 patients with paroxysmal atrial fibrillation who were diagnosed in the department of cardiology at Union Hospital of Fujian Medical University between April 2008 and 2009 March.All patients underwent circumferential pulmonary vein ablation plus left atrial linear ablation(CPVA)and were received blank control before and after the procedure.32 patients with paroxysmal atrial fibrillation who underwent CPVA between April 2009 and 2010 March were in control group. In this groups,patients were assigned to receive atorvastatin before and after the procedure.Echocardiography was performed preoperatively,and immediately ,1 day,3day,5day,7day and 30day after surgery in all patients. Left atrial diameter,the peak velocity of A-wave in late diastole(VA),left atrial filling fraction(AFF),left atrial ejection force(AEF),the peak velocity of mitral annulus by tissue Doppler in late diastole(Va),were measured.Results1. One month after the procedure, left atrial anteroposterior dimension,inferosuperior dimension,mediolateral dimension were all decreased in both groups ,(P<0.01). Compared to control group , the atorvastatin group was more obvious on average,but there was not differece in statistics(P>0.05).2.In both groups, VA,AFF and AEF were distinctly decreased after the procedure(P<0.01),and were still below preoperative level one month after the procedure (P<0.01). Compared to control group , the atorvastatin group was more higher on average,but there was not differece in statistics(P>0.05).3. Va were significantly lower than preoperative level in both group after the procedure(P<0.01),and were still below preoperative level 1 month after the procedure (P<0.01). Compared to control group , the atorvastatin group was more higher on average,but there was not differece in statistics(P>0.05).Conclution1. If CPVA procedure were successfully performed in patients with atrial fibrillation, left atrial reconstitution can be reversed.Left atrial function would distinctly decreased after the procedure,and would not improve in a short time.2. The effects of Atorvastatin on left atrial fucntion and structure in patients with atrial fibrillation were not evident in a short time .