Life Quality Assessment In Patients With Vitiligo With SF-36 Health Survey Scale And Its Relationship With TCM Syndrome-type

Objctive To evaluating the quality of life for patients with vitiligo by SF-36 scale;investegate the feasibility about the use of SF-36 scale to survey the quality of life for patients with vitiligo;as well as explore initially the relationsip between SF-36 values and TCM Syndrome typing.Materials and methods1.Using general items questionnair,SF-36 health survey questionnaire in Chinese (translated by Department of Social Medicine, Zhejiang University School of Medicine in 1991) and vitiligo lesion characteristics and clinical symptoms questionnaire to test 306 outpatients with vitiligo.Analyzing the various factors involved and clinical manifestations.2.Analyzing SF-36 scale on the internal consistency, split-half reliability, content validity, construct validity, discriminant validity.3.Establishing Epidata 3.02 software database, using SPSS17.0 and SAS9.0 software for statistical analysis.Single factor analysis, descriptive analysis (t test, variance analysis), chi-square test, etc….Scale feasibility analysis include correlation analysis, principal component analysis and factor analysis.Results1.Vilitigo group of 320 questionnaires were distributed,306 were recovered, the effective response rate of 95.62%;healthy control group of 200 questionnaires were distributed,200 were recovered, the effective response rate of 100%.2.The average age of onset of vitiligo is 27.33±13.13 years(2 to 65 years);the onset age of vitiligo mainly concentrates between 21 and 30 years; gender and vitiligo family history had no effect on the onset of the age.3.42 patients of 268 are associated with itching,29 patients with halo nevus,64 patients with Koebner phenomenon.Halo nevus and Koebner phenomenon are distributed in five types of vitiligo lesions.4. The Cronbach's a coefficients of eight scales is all above 0.6 except GH and SF,and most of the correlation coefficients between eight scales are smaller than Cronbach's a coefficient of SF-36.The split-half reliability coefficient of the SF-36 was 0.835.Most of correlation coefficients between every item and its own scale are above 0.7.The principal components analysis identified two common factors which were physical factor and a mental factor.They can be used to explain 55.93% of the total variance.The actual structure about the physiological factor and psychological factor identified by factor analysis is consistent with the theoretical structure of SF-36. 5.The scores of GH,VT,SF,RE,MH of vitiligo patients are significantly lower than the healthy peoples' and the difference is significant.Gender, age, education, occupation, marital status, economic status, vitiligo disease duration, location, activity, single or bilateral, lesion area, effect of past and onset seasons relate with quality of life of vitiligo patients. Family history, Koebner phenomenon, itching associated with vitiligo have no effect on the quality of life.6.TCM syndromes of vitiligo are mainly liver qi stagnation and liver and kidney deficiency which respectively were 102 cases (38.2%)and 82 cases (30.71%),and then followed by wind and damp invasion type 41(15.36%),24 cases of blood stasis type (8.99%),qi and blood deficiency type 13 cases (4.87%), spleen and stomach deficiency type 5 cases (1.87%).TCM syndrome differentiation of vitiligo have no significant difference between the vulgaris type and segmental type.Segmental type of vitilgo is mainly liver qi stagnation type,accounted for 48.78%.TCM syndromes of vitiligo have quite different scores of SF-36,the scores of wind and damp invasion type are highest,the scores of liver qi stagnation type are lowest.The MCS scores of liver qi stagnation type are significantly lower than the other TCM syndromes.There are significant differences between liver qi stagnation type and wind and damp invasion type,blood stasis type,liver and kidney deficiency.Conclutions 1.The Chinese version of SF-36 scale has good reliability and validity, and can be applicable for quality of life assessment in patients with vitiligo.2. All aspects of quality of life of vitiligo patients,including physiology, psychology and social functioning, are affected to various extents, their quality of life significantly decreased, especially in mental health.3.TCM syndromes of vitiligo have quite different scores of SF-36,the scores of liver qi stagnation type are lowest.