Clinical Research On Presciption Of Removing Heat And Eliminating Blood Stasis To Interfere In The Syndrome Stagnated Heat Of Diabetic Cardiomyopathy

Purpose:To discuss the understanding of traditional Chinese medicine about diabetic cardiomyopathy,using prescription of removing heat and eliminating blood stasis.To observe the therapeutic efficacy of this method in treating the syndrome stagnated heat of diabetic cardiomyopathy.Methods:A randomized,controlled trial was conducted 50 patients with the syndrome of stagnated heat of diabetic cardiomyopathy were randomly classified into two groups.On the basic of normal treatment and modern medicine,the patients of treated group (n=25) were treated by Chinese medicine while the patients of controlled group (n=25) were not.Three months was a course of treatment.The observed indexes included both curative effect indexes,such as clinical symptoms,FBG,PBG, HbAlc, blood fat, hemorheology and inflammatory factor hs-CRP,IL-6, index of left ventricular structure and function,and safety indexes,such as routine urine,blood and stool test,ECG,the function of liver and kidney and harmful reaction.The complete data carries on statistics analysis by the SPSS16.0 statistics software.Results:Prior treatment,the gender,age,course of disease of the two groups patients had no differeces.①The total effective rate of treated roup patients was 84.00%; while the controlled group was 44.44%.The treated group had an advantage than the controlled group(P<0.05).②The postprandial blood glucose, HbAlc of two groups were lowered(P<0.01). And the treated group had an advantage than the controlled group(P<0.05).③Compared with pre-treatment, in the treated group patients'TC,ApoB had a lowering(P<0.05),and TG,LDL-C,ApoB,ApoE,Lp (a) had a lowering and HDL-C, ApoA had marked increased(P<0.01), showing that the combination of Western medicine and chinese medicine has the function of adjusting fat and it does much better than using western medicine effected only in TC and HDL-C.④After treatment,the whole blood viscosity (highly cuts,middle cuts,lowly cuts5/s, lowly cutsl/s),the blood plasma viscosity and the ESR of the treated group dropped.The whole blood viscosity (lowly cutsl/s) and the ESR of the controlled group dropped.The dropping of the whole blood viscosity (lowly cutsl/s),the blood plasma viscosity and the ESR between treated group and controlled group had a remarkable difference (P<0.01), but the drop level of the whole blood viscosity (highly cuts,middle cuts,lowly cuts5/s),the blood plasma viscosity in the controlled group had no obvious difference.⑤Inflammatory hs-CRP, IL-6:After treatment, hs-CRP, IL-6 of treated group had a significant difference (P<0.01), compared with the control group were different (P<0.05).Compared with pre-treatment,IL-6 of the control group also significantly improved (P<0.01), but no significant difference in hs-CRP (P>0.05).⑥Left ventricular structure indicators:After treatment, LAD, LVID, IVSD, LVPWd were significantly decreased, LAD, IVSD were different compared with before treatment (P<0.05), LVID, LVPWd before treatment were significantly different (P<0.01); the control group after treatment LVID, LVPWd were different compared with before treatment (P<0.05), LAD, IVSD and treatment showed no difference (P>0.05); after treatment between the two groups, treatment group LVID, IVSD had more improvement than the control group (P<0.05), LAD to improve the treatment group than in the control group there was significant difference (P<0.01), but no significant difference before and after treatment IVSD (P>0.05).⑦Left ventricular function indicators:Indicators of left ventricular structure after treatment were significantly lower compared with before treatment and were significantly different (P<0.01); the control group after treatment PeakA,E/A there were significant differences (P<0.01), FS are different compared with before treatment (P<0.05), EF, PeakE and treatment showed no difference (P>0.05); comparison between the two groups after treatment, the treatment group improved significantly compared with the control group difference (P<0.01).⑧Safety indicators:Liver and kidney function tests were within normal range. Both groups were no adverse reactions.Conclusion:Chinese medicine of method in removing heat and eliminating stasis has sure curative effected in treating diabetic cardiomyopathy. It is worth studying deeply and developing further.