Edaravone On Large Cerebral Infarction Patients With Blood Serum MMP-9 Expression

Objective:To explore the relationship of serum matrix metalloproteinase-9 (MMP-9) and large area of cerebral infarction, the mechanism of Edaravone and the relationship of Edar-avone and the blood stasis syndrome.Methods:Select 30 patients of large area of cerebral infarction which admission within 48 h-ours after the pathogenesis,and randomly divide into normal group and treatment group,each of which has 15 patients. Normal group has 7 males and 8 females, age between 57-85;Treat-ment group has 7 males and 8 females, age between 44-87.Then select another group(normal control group) has15 patients,7 males and 8 females,age between 49-85. Normal group were using normal therapy (dehydration reducing the intracranial pressure, anti-platelet aggregation, lowering fiber, control blood pressure treatment), treatment group used Edaravone in the base of normal group therapy, infusion of 30mg/times,2 times/day, continue for two weeks. Use Stroke Scale (NIHSS) of the U.S. National Institutes of Health to recorded the neurological impairments of the normal group and treatment group before and after their admission. Patie-nts in each group which fasting in the morning were collect blood of Cubital Vein 5ml, inl,5, 15days after Admission,and using enzyme-linked immunosorbent assay double antibody san-dwich ELISA to detect the level of MMP-9. And then the results were statistically analyzed by using SPSS13.0 package.Results:1 MMP-9 in patients of large area of cerebral infarction compared with the normal control group.pre-treatment serum concentrations of MMP-9 in Edaravone treated group and normal group, compared with the normal control group was significantly higher, P<0.05, has signific-ant difference; A group compare with B group, P>0.05, no significant difference,the two gro-us were comparable.2 To compare the concentration of MMP-9 between the treatment group and normal group, before and after treatment.The concentration of MMP-9 in A, B groups has significant difference, P<0.05, in 1,5, 15 days after treatment.In the 5,15 days of two groups, The concentration of MMP-9 was lo-wer than those in the 1 day. A and B group had significant difference, P=0.002,<0.05, and the treatment group decreased the concentration of MMP-9 was obvious than the normal gro- up.3 To compare the efficacy between the treatment group and the normal groupUsing Ridit analysis, showed that number of normal group R were 0.6146, and treatment group R were 0.3854, two groups had significant difference, P<0.05, treatment group was significantly superior to the normal group.4 To compare the integral of the blood stasis syndrome between the treatment group and normal group,before and after treatment.The results showed that, the integral of the blood stasis syndrome in A, B groups has a significant difference, in 1,5,15 days after treatment, P<0.05.In the 5,15 days of two groups, the integral of the blood stasis were more significantly reduced then in the 1 day of two group5 The relationship between the concentration of MMP-9 and the degree of neurological deficitFor all patients of cerebral infarction within 48 hours after pathogenesis, analyzed the correlation between the MMP-9 levels (ng/ml) and the period of the NIHSS score,showed that MMP-9 has a positive correlation with the NIHSS, they had linear correlation, the correlation coefficient r=0.884 (P=0.000<0.05).6 The relationship between the concentration of MMP-9 and the integral of the blood stasis syndrome in stroke patients.For all patients of cerebral infarction within 48 hours after pathogenesis, analyzed the correlation between the MMP-9 levels (ng/ml) and the period of the integral of the blood stasis syndrome, showed that they have non-linear correlation, P=0.578>0.05. 7 The relationship between the integral of the blood stasis syndrome in stroke patients and the NIHSS score.For all patients of cerebral infarction within 48 hours after pathogenesis, analyzed the correla-tion between the integral of the blood stasis syndrome and and the period of the NIHSS score, sho-wed that they have non-linear correlation, P=0.344>0.05.Conclusion:1 MMP-9 level with a defective functional(NIHSS)ratings, which are associated with MMP-9 reflect a cerebral infraction patients'condition.2 Edaravone serve as a new type of oxygen radicals clean and in the area of infarction of the therapeutic and may MMP-9 serum have a restraining. Edaravone oxygen radicals may thro-ugh improved metabolic to improve the type of blood stasis.3 MMP-9 level and blood stasis card number is the line between MMP-9, not as a stroke ill blood stasis certificate of an objective index once dialectical.4 Blood stasis card number and grade NIHSS no line between stasis card number and blood cannot reflect a stroke was a function of the acute, with cerebral infraction of the seriousness of the extent of acute illness is obvious.