Association Of MVP With Non-alcoholic Fatty Liver Disease

Objective: Mean platelet volume (MPV) is an indictor of platelet activation. Platelet activation and aggregation are central processes in the pathophysiology of coronary heart disease(CHD). Non-alcoholic fatty liver disease (NAFLD) is present up to one–third of the general population and the majority of patients with cardio-metabolic risk factors such as abdominal obesity, type 2 diabetes and other components of the metabolic syndrome (MS). The aim of the current study was to investigate the MPV in patients who had NAFLD.Methods: The level of MPV was measured in 50 normal controls and 65 patients with NAFLD. A statistically analysis of the data was conducted.Results:①MPV values of the patients with NAFLD and of the patients without fatty liver disease were compared.Among biochemical variables, fasting plasma glucose and triglyceride were significantly higher in the NAFLD group. NAFLD cases also had lower platelet count and higher MPV (10.43±1.14 vs. 9.09±1.25; p < 0.001, respectively). ②MPV was positively correlated with AST (r=0.186, p < 0.042), ALT level (r=0.279; p= 0.002) and the presence of NAFLD (r=0.492; p < 0.001) but negatively correlated with platelet number (r=?0.26; p=0.004) and creatinine (r=?0.255; p=0.005).③In logistic regression analysis [age, gender, NAFLD, high-density lipid cholesterol (HDL-C), systolic and diastolic blood pressure (SBP, DBP), triglyceride (TG) and fasting plasma glucose (FPG) were used as covariates] only NAFLD was found to be the independent predictor of MPV (Odds Ratio (OR) 21.98) [95% confidence interval (CI): 2.404–201.048; p= 0.006].Conclusions: Patients with NAFLD have higher MPV. It may,to some extence, have prognostic value in NAFLD patients indicating a possible cardiovascular disease (CVD).