The Effects Of Rabeprazole On Symptoms And Psychological Status In Non-erosive Reflux Disease

ObjectiveTo investigate the characteristics of symptoms and psychological factors of patients with NERD and evaluate the efficacy of four-week rabeprazole therapy.Meterials and methodsWe selected subjects in the First Affiliated Hospital, Chongqing Medical University between October 2009 and January 2010.All consecutive patients aged between 18 and 80 years who complained regurgitation and heartburn and underwent endoscopy in the absence of esophageal mucosal damage for the first time were entered into the study. We excluded the patients with history of cardiovascular disease and taking Histamine2 receptor antagonist(H2RAs) and antacid. Patients who were interviewed to find out the GerdQ score was≥8 score were diagnosed NERD. Patients received rabeprazole 10mg qd for four weeks. The change of symptoms and psychological factors after treatment with rabeprazole for four weeks were followed.Results1. Clinical data of NRED patients159 NERD patients completed 4-week treatment. 44 were males and 115 were females. Mean age of the responders was (44.75±11.75)yr.GerdQ score was 10.44±1.62, SAS score was 47.11±10.92, SDS score was 44.59±11.28. The incidences of heartburn (87/159, 54.72%) and regurgitation (114/159, 71.70%) were higher than nausea (75/159, 47.17%), insomnia (73/159, 45.91%), globus sensation (84/159, 52.83%),epigastric pain (40/159, 25.16%), abdominal distension (43/159, 27.04%) and chronic cough (26/159, 16.35%).The incidence of anxiety and depressive symptoms were 42.77% (68/159) and 38.36% (61/159).There was correlation between GerdQ and SAS or SDS .2. Comparison of symptoms after treatmentAfter four weeks treatment, the remission rates of heartburn ( 82.80%vs57.80%, P=0.005),regurgitation (71.50%vs61.63%, P=0.005), nausea(64.90%vs53.47%, P=0.005), epigastric pain (66.90%vs54.85%, P=0.005) and insomnia(67.40%vs56.72%, P=0.005) were significantly higher than one week. After four weeks treatment,the general availability rate of NERD (84.91%vs72.96%,P<0.05) was significantly higher than one week.3. Comparion of clinical score before and after treatmentAfter one week treatment,SAS score (43.07±10.47vs47.11±10.92, P=0.005) and SDS score(40.60±10.98vs44.59±11.28, P=0.001) were significantly lower than before.After four weeks treatment,SAS score (39.56±9.74vs43.07±10.47, P=0.005) and SDS score(36.99± 10.46vs40.60±10.98, P=0.001) were significantly lower than one week.ConclusionWhen treating NERD patients with rabeparazole, symptoms and psychological factors can be improved.