Retrospective Analysis Of The Predictive Effect Of Laboratory Indicators On The Prognosis Of Intracerebral Hemorrhage

Objective: Intracerebral hemorrhage(ICH) is a disease with high mortality and high morbidity, there is still lack of effective treatment measures, and the turnover cannot be predicted easily. Pathophysiological changes after ICH are complex, but maybe reflected by the changes of laboratory indicators. Therefore, the relationship between the changes of laboratory indicators after ICH and disease outcome deserves further research. In this study, we try to find the effective laboratory indicators after acute intracerebral hemorrhage for predicting the turnover of the ICH.Methods: According to the turnover, 582 patients of ICH were divided into two groups: effective group(including healing well and improving), ineffective group(including non-improving and dying). The results of laboratory indicators were analyzed between groups with SPSS software 13.0, including coagulation-related indicators (PLT, PDW, MPV, PT, APTT, TT, Fbg, D-D) and biochemical indicators (TC, TG, HDL-c, LDL-c, UA, Glu).The differences of these indicators was found by independent-samples T test or Mann-Whitney test between groups, depending on their Levene's Test. In addition, the odds ratio(OR) of the statistically significant indicators, was calculated by chi-square test, respectively.Results:1. Among the coagulation-related indicators, PLT, PT and D-D had significant differences between groups (P<0.05). By chi-square test, the OR of decreased PLT was 1.75 (1.10~2.72 with 95% confidence interval,95%CI), that of elongated PT was 2.69(1.20~6.04 with 95% CI), that of increased D-D was 2.13(1. 02~4.43 with 95% CI).2. Among the biochemical indicators, HDL-c, UA and Glu had significant differences between groups (P<0.05). By chi-square test, the OR of increased UA was 1.94(1.16~3.25 with 95% CI), that of increased Glu was 1.73 ( 1.46~2.05 with 95%CI), while that of increased HDL-c was 0.91(0.45-1.85 with 95%CI) without statistically significant. Conclusion: Decreased PLT , elongated PT , increased D-D, UA and Glu are the risk factors for the prognosis of ICH, monitoring and controlling the PLT, PT, D-D, UA and Glu maybe good suggestions for improving the prognosis of ICH.