Expression And Pathological Significance Of RECK And MMP-9 In Cutaneous Squamous Cell Carcinoma

Objective:To investigate the expression of RECK and matrix met alloproteinase-9 (MMP-9) protein and their correlations with the occurrence, development, invasion and metastasis of cutaneous squamous cell carcinoma(CSCC).Methods:SP immunohistochemical method was used to detect the expression of RECK and MMP-9 protein in 40 cases of CSCC,17 cases of adjacent atypical hyperplasia(AH) and 14 cases of normal cutaneous epithelium (CE).Results:â‘ The expression rate of RECK protein was increased gradually in CSCC, AH and NE, which was30.0%,47.1%,85.7%respectively, and there was significant difference between every two groups(P<0.05). However, the expression rate of MMP-9 protein was decreased gradually in CSCC, AH and CE which was 82.5%,76.4%,28.6%respectively, and their difference in each group has the statistic significance(P<0.05).â‘¡Both RECK and MMP-9 expression in CSCC was associated with with the tumor grade infiltration and lymph node metastasis. The difference was significant (P< 0.05).â‘¢RECK expression had negative correlation with MMP-9 expression (r=-0.475, P<0.01).Conclusion:RECK and MMP-9 may play important roles in the invasion and metastasis of CSCC. The down-regulation or loss of RECK expression stimulates migration and metastasis of CSCC by up-regulating MMP-9 expression.