Cross-sectional Investigation On Renal Bone Disease In Hemodialysis Patients From Single Centers

Objective:To understand the bone metablism and the controling situation of the bony disease in maintenance hemodialysis(MHD) patients at our hospital hemodialysis center, to analyze the reason and the related factors.Methods:To investigate the renal bone disease datas(Ca,P,Ca×P,PTH) of 113 MHD patients in hemodialysis centre of our hospital,then to compare with the bone metabolism and the bony disease controling recommended in Kidney Disease Outcome Quality Initiative (K/DOQI) guidelines. To analyze the reasons for not achieving the standard and the relationship between these datas and age, gender,Kt/V, BMI, year for dialysis, renal function, blood pressure, Hb and CRP.Results:54.0% of patients had the normal levels of serum Ca,39.8% had the normal serum P, 63.7% of patients fell within recommended ranges for Ca×P, and 31.0% were within the values of the PTH. Overall, only 17.7% of patients achieved the four recommendations provided in the K/DOQI guidelines. Single and multiple variable analysis showed that there were no relationship between the sex, age, CRP, Kt/V, the year for dialysis and renal osteodystrophy.Serum creatinine, Hb, BMI and blood pressure≥140/90 mmHg were the main risk factors.Serum creatinine, Hb and hypertension were independent factors of the bone metablism and the control of the bony disease.Conclusion:The bone metablism and the control of the bony disease in most hemodialytic patients still cannot reach the K/DOQI guidelines. The occurrence of the renal osteodystrophy was closely related to serum creatinine, Hb and blood pressure.