| Objective:To detect of the serum level of osteopontin (OPN) in systemic lupus erythematosus (SLE) patients, and analyze the correlation between OPN and other clinical and laboratory datas, and explore the importance of OPN in the pathogenesis of disease activity as well as organ damage.Method:The serum level of OPN was measured by immunoenhancement in 63 SLE patients and 20 healthy controls. Based on the SLEDAI,the 63 SLE patients were divided to active SLE group and inactive SLE group.Based on the 24-hour urine protein excretion, the patients were divided to SLE with renal damage group and SLE without renal damage group. Based on the interstitial pulmonary fibrosis index, the patients were divided to SLE with ILD group and SLE without ILD group, and the SLE with ILD group were divided to interstitial pulmonary group and interstitial pneumonia group based on the description of high-resolution computed tomography(HR-CT). Based on the electrocardiogram and echocardiogram,the patients were divided to SLE with heart damage group and SLE without heart damage group.Based on the diagnostic criteria of SLE and hematological abnormality, the patients were divided to SLE with cytopenia group and SLE without cytopenia group. Based on the symptom and sign of SLE, the patients were divided to SLE with arthritis group and SLE without arthritis group.Based on the family history of SLE, the patients were divided to SLE with positive family history group and SLE negative family history group. The collected datas were analyzed by SPSS15.0.Result:(1) The level of serum OPN was significantly higher in SLE group than that in the healthy controls (mean:74.86 ng/ml VS 20.83 ng/ml, t=12.06,p=0.000<0.01).(2) The level of serum OPN was significantly higher in the active SLE group than that in the inactive SLE group (mean:91.94 ng/ml VS 57.23 ng/ml,t=12.08,p=0.000 <0.01).(3) The level of serum OPN was significantly higher in the SLE with renal damage group than that in the SLE without renal damage group (mean:83.92 ng/ml VS 65.50 ng/ml, t=2.037,p=0.000<0.01).(4) The level of serum OPN was higher in the SLE with ILD group than that in the SLE with ILD group (mean:81.98 ng/ml VS 71.04 ng/ml,t=2.037,p=0.046<0.05).(5) The level of serum OPN was significantly higher in the interstitial pulmonary fibrosis group than that in the interstitial pneumania group (mean:93.40 ng/ml VS 72.46 ng/ml,t=4.051,p=0.001<0.01).(6) The level of serum OPN was significantly higher in the SLE with heart damage group than that in the SLE without heart damage group (mean:84.46 ng/ml VS 68.54 ng/ml,t=3.178,p=0.002<0.01).(7) The level of serum OPN was significantly higher in the SLE with cytopenia group than that in the SLE without cytopenia group (mean:82.98 ng/ml VS 54.56 ng/ml, t=6.193,p=0.000<0.01).(8) The level of serum OPN was no difference between the SLE with arthritis group and the SLE without arthritis group (mean:75.58 ng/ml VS 74.07 ng/ml, t=0.258, p=0.777>0.05).(9) The level of serum OPN in the SLE group showed positive correlation with 24-hour urine protein excretion, SLEDAI, anti-ds-DNA level, RBC and HGB respectively, and negative correlation with C3 level, but no relationship was foud with IgG, IgA and so on.Conclusion:(1) The level of serum OPN in the SLE group elevated compared to the controls, which suggest OPN may take part in the pathology of SLE.(2) The level of serum OPN in the active SLE group elevated compared to the inactive SLE group, and showed a positive correlation with active index such as SLEDAI,24-hour urine protein excretion, anti-ds-DNA level, and negative correlation with C3 level, wich suggest OPN may be related with the activity of the disease, and may be a inflammation index of judging the activity of SLE.(3) Patients with renal damage,lung interstitial disease,cytopenia,their serum level of OPN were higher than that of patients with non-organ involvement, wich suggest OPN, as a proinflammatory,may take part in the pathological process of organ damage in SLE, and may be a marker of organ damage. |
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