Clinical Observation Of Dried Toad Venom Liniment Treatment Of Primary Premature Ejaculation

OBJECTIVE:Through the observation clinical curative effect of the traditional Chinese medicine dried toad venom liniment treat primary premature ejaculation, for clinical uses the Chinese medicine treatment premature ejaculation to provide an effective way.METHODS:1 Observation of the crowd:in line with primary premature ejaculation(PE), the male patient from 18 years old to 50 years old.2 Observation medicines:The treatment group medicine:Dried toad venom liniment (medicine composition:Dried toad venom 3g, asarum 2g, datura flower 4g, gall nut 5g, clove 3g, menthol 3g. With 30% alcohol soaked 7 days after the supernatant back. from the hospital preparation room preparation.) The control group medicine:Tetracaine Hydrochloride Jelly (Lijunjinghua pharmaceutical industry by Xi An).3 Total number of cases:72 patients of primary premature ejaculation were randomly divided into two groups. The treatment group had 36 patients, the control group 36 patients.4. Treatment programs, treatment course, and visits system Dried toad venom liniment:External use, half an hour before sexual intercourse, treatment course 4 weeks. Tetracaine Hydrochloride Jelly:External use, half an hour before sexual intercourse, treatment course 4 weeks。The patient must go back to hospital at the end of two weeks and four weeks, so that the doctor can learn the conditions of patients.5 Curative effect indicatrix CISFPE score and intravagina ejaculation latency time(IELT) and sexual life satisfaction score (SSS)6 Safety index Blood-Rt, Urine-Rt, LFT,BUN,Cr, ECG.7 Adverse events observed:To observe whether the glans penis, swelling, pain, itching, rash, burning sensation and numbness caused by penile erection will not be strong, etc.; while the female whether vaginal hypoesthesia and vaginal discomfortResults:(1) Into the group and achievement:the treatment group 36 cases, 36 cases in the control group, two groups of patients without loss.(2) The average IELT (min) for comparison:The treatment group before treating for 0.61±0.11, treating 2 weeks later for 3.6±1.14, treating 4 weeks later for 3.8±1.52; The control group before treating for 0.60±0.12, treating 2 weeks later for 3.7±1.15, treating 4 weeks later for 3.8±1.41. The two groups in the treatment of 2 weeks and 4 weeks later, lengthens patient's IELT obviously, P<0.05. Around the treatment group and the control group, the average IELT for comparison is not obvious difference, P>0.05.(3) Average CISFPE score comparison:The treatment group before treating is 10.03±2.72, treating 2 weeks later for 14.16±3.15, treating 4 weeks later is 18.50±4.09; The control group before treating for 10.10±2.75, treating 2 weeks later for 12.17±3.11, treating 4 weeks later for 15.11±3.12. Around the treatment group and the control group treatment the average CISFPE score comparison to have the significance difference, P<0.05.(4) The average sexual life satisfaction score (SSS) comparison: The treatment group before treating is 8.2 earth 1.2, treating 2 weeks later for 14.1±1.5, treating 4 weeks later is 14.2 earth 1.5; The control group before treating for 8.1±1.4, treating 2 weeks later for 11.7±1.4, treating 4 weeks later for 12.1±1.3. Around the treatment group and the control group treatment the average sexual life satisfaction score comparison to have the significance difference, P<0.01.(5) Safety TestingThe treatment group and the control group were not apparent serious adverse events, indicating that this drug safe and reliable. Conclusion:The dried toad venom liniment can obviously improve patient's symptom, lengthens patient's IELT obviously, enhances the patient and the spouse to sex life satisfaction, improves the patient to the semination control, the alleviation anxious, the tense mood as well as decreases the medicine side effect, improves the quality of life. Between the control group and the treatment group is lengthening patient's semination incubation period non-significance difference, but the treatment group is enhancing the patient and the spouse has the significance difference to sex life satisfaction as well as the CISFPE grading.