Research On The Internal Radiation Therapy Absorbed Dose For Nano-iron Nuclide

Treatment of internal exposure to radionuclides is a young discipline, it can simultaneously irradiated multiple lesions in the whole body, and on the control of small lesions metastasis has its unique advantage, it has been a hot topic in cancer therapy. Nano-iron nuclide is a new high-purityβ-particle radiation, high magnetic targeting and a relatively short half-life of radioactive substances, it can meet the radiation requirements of internal radiation therapy. Nano-iron nuclide has a unique physiology can be capacitive and superparamagnetic, in guiding magnetic field it can be directed transport and local enrichment. And Nano-iron nuclide can both carry drugs but also has radioactive, so can Set radiation therapy and chemotherapy together for the treatment of cancer. Besides its physical properties meet the requirements of clinical internal radiation radiotherapy, and no radioactive decay of daughters, without causing any pollution in human body.First, this paper introduces the radionuclide radiotherapy for cancer research background, as well as the basic theory related to internal exposure; Then introduced the preparation of nano-iron oxide nuclide, and preliminary analysis of its performance. Analysis of results: From the electron microscope observation, size to nanometer level, appearance of a uniform size, and has good dispersion characteristics; nano-iron oxide nuclide is superparamagnetic, and would not affect its paramagnetic into the reactor by the irradiation; Nano-iron oxide nuclide has radioactive, Compared with the nano-iron nuclide, the radioactive is slightly weaker, but its more widely used in drug delivery. Nano-iron oxide nuclide. The main contribution of iron oxide nano-energy radiation from the 2569Fe, Decay mode is theβdecay,Maximum energy is 1.565MeV, The average energy is 0.371MeV, its apply to targeted radiotherapy. Second, using two different model to calculate nanometer-iron nuclide absorbed dose due to the treatment of liver cancer. The first method is the conclusion that: only needs 5. 786×10?4mg nanometer-iron nuclide can causing 100Gy absorbed dose witch considered as the liver tolerance dose. The second method is the conclusion that: The peripheral dose that 0.35cm from the center of a circle is 42.5A, and 57A for cumulative dose. Then this paper also use two kinds of estimation methods in the same volume of tumor, directly compare the two methods' different of total dose and the dose rate distribution of the different points, the conclusion is: The first method is better than the second method by only consider the effect; The first method's clinical administration is simple, to reduce pain in patients, the second method is suitable for the situation to be considered peripheral dose; End of the paper summarizes the advantages and disadvantages of nanometer-iron nuclide for internal radiation therapy, and outlook to future work.