Ischemia Modified Albumin In Acute Cerebrovascular Disease

Objective: To study the relationship between ischemia modified albumin(IMA) and acute ischemic cerebrovascular diseases, to explore whether IMA can be used as a sensitive biochemical marker of cerebral ischemia, to investigate the correlation between IMA and cerebral infarct volume, the extent of clinical neurological deficits, and to provide new experiment evidence for the early diagnosis and treatment of acute cerebrovascular disease.Methods: The level of serum IMA was measured serially by enzyme linked immunosorbent assay(ELISA), and the levels of serum lipid and albumin were measured by automatic biochemical analyzer in 55 cerebral infarction, 30 intracerebral hemorrhage, 12 subarachnoid hemorrhage and 30 age-matched healthy control subjects.Results:1. There was a statistically significant different between the mean level of serum IMA in CI group, ICH group, SAH group and the healthy control group (P<0.01). Furthermore, the mean level of IMA in CI group was significantly higher than this of other groups(P<0.01), the mean level of IMA in ICH group were higher than this of SAH group and healthy control group(P<0.01), the mean level of IMA in SAH group was higher than healthy control group(P<0.01)2. There was no correlation between the level of serum IMA and TC, TG, LDL-C, HDL-C and ALB in patients of CI, ICH and SAH group (P>0.05). We observed significant correlations between the level of serum IMA and LDL-C in healthy control group (P<0.05), but no correlation was observed between IMA and TC, TG, HDL-C and ALB (P>0.05).3. We make out the relative operating characteristic curve (ROC) based on the data got from the tests of ACD patients. From the ROC curve we know that when the cut off value of IMA level is 79.85U/mL, the summation of the sensitivity value (0.818) and the specificity value (0.858) in ACB test is the greatest, and the positive diagnosis of was 89.09%.4. The level of serum IMA in big infarct volume group, middle infarct volume group and small infarct volume group were not significantly different (P>0.05). There was no correlation between infarct volume, the extent of nuerological deficits and the level of serum IMA (P>0.05).Conclusions:1. The level of serum IMA in ACD patients was significantly higher than healthy control group. IMA may be a sensitive but nonspecific biochemical marker of cerebral tissue.2. There was no correlation between the level of serum IMA and TC, TG, LDL-C, HDL-C and ALB in ACD patients.3. IMA may be used as a new laboratory method to identify CI, ICH and SAH.4. There was no correlation between infarct volume, the extent of nuerological deficits and the level of serum IMA...