| Objective:To study character of cognitive impairment and depression in patients with cerebral infarction, and research the relationship between them. And to discuss the difference of the cognitive status of left and right hemisphere lesions,and the relationgship between the risk factors and cognitive impairment and depression after cerebral infarction, such as diabete mellitus, hypertension .Methods:Collecting 42 patients within the first 1 month of cerebral infarction and 40 cases of healthy controls in the Department of Neurology at the First Affiliated Hospital of Chongqing Medical University from May 2009 to February 2010.Using Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), Hamilton Depression Scale (HAMD) , 42 patients with cerebral infarction and 40 controls were assessed cognitive function and depression, and were statistically analyzed and compared the results between the two groups, and analysis cognitive of left and right side of the status.According to the results of HAMD score, the patients were divided into the cerebral infarction patients with depression group (PSD) and not with depression group (non-PSD), and were compared between the MMSE, MoCA score.According to whether patients with hypertension or not , the patients were divided into hypertension group and non-hypertension group ,and were compared between the two groups ,the scale (MMSE, MoCA, HAMD) score results.According to whether patients with diabetes mellitus or not, the patients were divided into diabetic group and non-diabetic group ,and were compared between the two groups ,the scale (MMSE, MoCA, HAMD) score results.Results:1 42 patients with cerebral infarction, in which the left hemisphere infarction 24 patients, 18 cases of right; PSD group of 13 cases, 29 cases of non-PSD group; combined hypertension in 23 cases, 19 cases of non-hypertensive patients; 17 cases of diabetes, 25 cases of non-diabetics; and the control group of 40 patients; cerebral infarction between groups and control groups in gender, age, educational, by t test andχ2 test, the difference was not significant(p> 0.05).2 MMSE score was 24.31±5.40 in patient group, compared with the normal group 27.23±2.64 ,the difference was statistically significant (p <0.05) .The first screening of cognitive function in patients with cerebral infarction was 47.6%. MoCA score was 21.55±6.43 in patient group, compared with the normal group(27.20±2.08) ,the difference was statistically significant (p <0.05) . One patient group score≤26 points were 27 cases .The incidence of cognitive impairment post cerebral infarction was 64.3%. HAMD score was 5.29±3.89 in patient group, compared with the normal group(1.88±1.89) ,the difference was statistically significant (p <0.05) . One patient group score≥8 points were 13 cases.The incidence of post stroke depression was 31.0%.3 MMSE score of the left lesion group was 23.92±4.46, the right lesion group 24.83±6.56, the difference was not statistically significant (p> 0.05). MoCA score of the left lesion group was19.63±6.37, compared with the right side 24.11±5.71,the difference was statistically significant (p <0.05). HAMD score on the left lesion group was 6.71±3.58, the right side 3.39±3.45, the difference was statistically significant (p <0.05).4 MMSE score of PSD group was 21.00±4.51, compared with non-PSD group 25.79±5.16, the difference was statistically significant (p <0.05). MoCA score of PSD group was 15.62±5.90, non-PSD group 24.21±4.69, the difference was statistically significant (p <0.05).And the cognitive score of PSD group was lower than non-PSD group.5 MMSE score of patients with hypertension 24.48±5.48, and non-hypertension group 24.11±5.47 ,the difference was not statistically significant (p> 0.05). MoCA score of patients with hypertension was 21.35±7.00, non-hypertension group 21.79±5.85, the difference was not statistically significant (p> 0.05) .HAMD score of patients with hypertension was 5.48±3.88, and non-hypertension group 5.05±3.92 ,the difference was not statistically significant (p> 0.05).6 MMSE score of the diabetic group was 22.29±4.25, and non-diabetic group 25.68±5.74, the difference was statistically significant (p <0.05); MoCA score diabetic group was 16.94±6.21, and non-diabetic group24.68±4.43, the difference was statistically significant (p <0.05); HAMD score of diabetic group was 7.71±4.01, and non-diabetic group3.64±2.78, the difference was statistically significant (p <0.05). The cognitive scores of diabetic group was lower than non-diabetic group, but HAMD score was higher in diabetic group .Conclusions:1 The incidence of post carebral infarction cognitive impairment and depression were very high, and the lesions are due to dysfunction of the left marked.2 Cognitive impairment and depression often occur simultaneously in patients with cerebral infarction, and the reciprocal relationship between the two seriously reduce the effectiveness of treatment and the quality of life in patients with cerebral infarction. 3 Cerebral infarction patients with diabetes mellitus are more obvious cognitive and affective disorders of depression .4 Hypertension had no significant effect on cognitive impairment and affective disorders of depression of post cerebral infarction. |
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