Association Between The Serotonin Transporter Gene Polymorphism And Personality Traits

Objective:To assess the association between serotonin transporter(5-HTT)gene polymorphism (including Stin2 and 5-HTTLPR)and the Eysenck personality Questionnaire(EPQ)personality dimensions in Chinese Han normal population,and to investigate the contribution of the 5-HTT gene to the personality.Methods:305 unrelated Chinese Han normal individuals were selected in our study with strict standards,general demography data were collected,three personality dimensions(Neuroticism, Extraversion and Psychoticism)were assessed with EPQ,calculate the standard scores(T)of three dimensions,and then divide the personality into two levels by the T50:Neuroticism and Non-neuroticism,Introversion and Extraversion,Psychoticism and Non-psychoticism;the polymorphism of Stin2 and 5-HTTLPR were detected by polymerase chain reaction(PCR). SPSS13.0 and UNPHASED software were used for single polymorphism association analysis: Personality means were compared with t-test and One-Way ANOVA;the genotype and allele frequency distribution were compared with x~2 analysis,Monte Carlo P were calculated. UNPHASED software were used to perform haplotype-analyze of Stin2 and 5-HTTLPR.Results:1.Hardy-Weinberg equilibrium testStin2 and 5-HTTLPR were obtained Hardy-Weinberg equilibrium(P＞0.05),which indicated that the sample can represent the population.2.Stin2 and personality2.1 Analysis in male①There was no statistically significant difference of each personality means between different Stin2 genotype and allele frequency.②There was no statistically significant difference of Stin2 genotype and allele frequency distribution between different personality dimension levels.2.2 Analysis in female①There was no statistically significant difference of each personality means between different Stin2 genotype and allele frequency.②There was no statistically significant difference of Stin2 genotype and allele frequency distribution between different personality dimension levels.3.5-HTTLPR and personality3.1 Analysis in male ①There was no statistically significant difference of each personality means among different 5-HTTLPR genotype and allele frequency.②There was no statistically significant difference of 5-HTTLPR genotype and allele frequency distribution between different personality dimension levels.3.2 Analysis in female①There was no statistically significant difference of each personality means among different 5-HTTLPR genotype and allele frequency.②There was no statistically significant difference of 5-HTTLPR genotype and allele frequency distribution between different personality dimension levels.4.Haplotype-analyze of Stin2 and 5-HTTLPRThere was no statistically significant difference of 12-L,12-S,10-L,10-S haplotypic frequency distribution between different personality dimension levels.Conclusions:1.The Stin2 gene polymorphism may have no association with the Neuroticism,Extraversion and Psychoticism personality in Chinese Han normal individuals.2.The 5-HTTLPR polymorphism may have no association with the Neuroticism,Extraversion and Psychoticism personality in Chinese Han normal individuals.3.The haplotype compared by Stin2 and 5-HTTLPR may have no association with the Neuroticism,Extraversion and Psychoticism personality in Chinese Han normal individuals.