Design, Synthesis And Bioactivity Of Hexahydrofuro [3,2-b] Furan - Imidazolium Salts

Cancer, also known as malignant tumors, is the second leading cause of death after cardiovascular diseases. Therefore, the development of new drugs with good antitumor activity is one of the focus areas of organic chemistry and medicinal chemistry. So far, chemists have isolated and discovered many bioactive natural products. Some of them possessing hexahydrofuro[3,2-b]furan and imidazole moieties are confirmed having excellent anti-tumor activity. In this thesis, a series of hexahydrofuro[3,2-b] furan-imidazolium salts compounds was designed and synthesized, and evluated on the cytotoxicity screening against a panal of tumor cell lines. The purpose was to find anti-tumorlead compounds with novel structure and high selective.This thesis consists of three chapters.In the first chapter, the research progress on biological activity of imidazole and hexahydrofuro[3,2-b]furan was briefly reviewed.In the second chapter,29 tetrahydrofuro[3,2-b]furan-single imidazolium salts were synthesized and investigated into the anti-tumor effect and analgesic effect.In the second chapter,24 hexahydrofuro[3,2-b]furan-double imidazolium salts were synthesized and investigated into the anti-tumor effect. The results showed that some of the imidazolium salts displayed high cytotoxic activity.Based on research of this thesis, further modifications and structure-activity relationships can be considered to improved the library of hexahydrofuro[3,2-b]furan-imidazolium salts compounds, in order to find the lead compounds with potent antitumor activity.