Studies On Synthesis And Anti-helicobacter Pylori Activities Of Arylacetamide Derivatives

Helicobacter pylori (Hp) is a spiral Gram-negative bacteriumwhich living in micro-aerophilic environment and was isolated andidentified in the stomach of patients with gastritis and peptic ulcer. Atpresent, triple or quadruple regimen which consists of a combination ofa proton pump inhibitor or bismuth agent and two or three antibacterialagents are main used to eradicate Hp in clinic. However, antibacterialagents used in this therapy show a broad and effective antibacterialrange, high dose application cause drug resistance increasing, as well assome side effects such as diarrhea, pseudomembranous enteritis werecaused by this therapy. Therefore, looking for new anti-Hp agents arousemany scholars interest. The new class of arylacetamide derivatives havehigh selectivity, acid resistance and simple structure characteristics, so itgives a new direction of anti-Hp agents study.In this dissertation, we summarized the progress on the structuralmodification and synthesis of anti-Hp derivatives, and their researchresults and progress of anti-Hp activity.Our mainly study was focused on the synthesis arylacetamidederivat-ives and anti-Hp activity. We synthesized a range ofN-(3-methylaminofor-mylphenyl)-arylacetamides and N-(3-bromophenyl)-ar-ylacetamides with a simple method.Using double agar dilution method, we studied on Hp inhibitoryactivity about ATCC700392Helicobacter pylori strain by some ofsynthe-sized compounds. The results indicated that compound2l and2b show asignificant antibacterial activity against Hp.