Synthesis Of Quinoline Aldehyde And Derivatives

Quinoline derivatives are widely used in medicine, pesticide and materials due totheir biological and pharmacological activity such as antibacterial, anti malarial, andanti-cancer.12of Quinoline carboxaldehyde compounds had been synthesized withAcetanilide,8-hydroxy quinoline and methylquinoline via several reactionsrespectively, such as cyclization, Reimer-Tiemann reaction, condensation hydrolysisand sodium periodate oxidation. Structure of4of8-hydroxyquinoline formaldehydederivatives yield from the Reimer-Tiemann reaction and condensation hydrolysis hadbeen characterized by the MP and1H-NMR and distinguish the differences amongthem. The synthetic procedure of8-hydroxyquinoline-5-formaldehyde compoundshad been optimized and the best reaction condition had been found out.11of9-quinolyl-2,4,5,7,9,10-hexahydroacridine-1,8-dione derivatives had beensynthesized with2-chloroquinoline-3-carbaldehyde or [2-(2-quinolinyl)ethenyl]benzaldehyde, dimedone and ammonium acetate under mild condition. A series of3,3,6,6-tetramethyl-9-{3-[quinolyl-2(1H)-one]}-2,4,5,7,9,10-hexahydroacridine-1,8(2H,5H)-dione derivatives had been obtained by catalyzing with acids instead ofexpected compounds of3,3,6,6-tetramethyl-9-[3-(2-chloroquinoline morpholinyl)]-2,4,5,7,9,10-hexahydro-acridine-1,8(2H,5H)-dione derivatives and the reactionmechanism was also conjectured.6of crystal structure had been identified by singlecrystal diffractometer.5high yield of3,3,3,6,6-tetramethyl-9-{3-[quinolyl-2(1H)-one]}-2,4,5,7,9,10-hexahydro xanthene-1,8(2H,5H)-dione derivatives had been synthesized with2-chloroquinoline-3-carbaldehyde, dimedone and DMF by Multi-component mixingreaction under mild condition. The crystal structure of b had been identified by singlecrystal diffractometer. The reaction between2-chloroquinoline-3-carbaldehyde anddimedone to yield xanthene derivatives is are similar to acridone derivatives. A seriesof3,3,6,6-tetramethyl-9-{3-[quinolyl-2(1H)-one]}-2,4,5,7,9,10-hexahydro xanthene-1,8(2H,5H)-dione derivatives had been obtained instead of compounds of3,3,6,6-tetramethyl-9-[3-(2-chloro-quinoline morpholinyl)]-2,4,5,7,9,10–hexahydroxanthene-1,8(2H,5H)-dione derivatives.6of4’-[3-(2-chloroquinoline)]-2,2’:6’,2’’-terpyridine derivatives had beensynthesized with2-chloroquinoline-3-carbaldehyde derivatives by cyclization. Thecrystal structure of b had been identified by the X-ray diffraction instrument. And thethree pyridine ring are almost on a plane. The angle between Quinolin ring and Pyridine ring is123°.