Study Of Drug Loading Methods On Porous Hollow Nano-Carriers

The method of loading avermectin into porous hollow silica nano-particles (PHSN) is an advanced controlled drug release technology. Controlled drug release systems offer numerous advantages over conventional formulations such as improved efficiency, reduced toxicity, and convenience. Porous hollow silica nano-particles (PHSN) has the ability of absorb UV radiation, therefore, can protect the entrapped actives from light-decomposition.The loading of avermectin into porous hollow silica nano-particles (PHSN) by different methods of vaporizing solvent (VS), anti-solvent precipitation (ASP) and supercritical fluids drug loading (SFDL) was investigated. The Total Loaded Drug (TD), the drug loaded inside the carriers (DI), the drug loaded outside the carriers (DO) and their sustained release behaviors of the avemectin-loaded PHSN were analyzed with thermal gravity apparatus (TG), a dissolution tester and a UV spectrometer. The results indicated that the highest TD, DI and best sustained release were achieved by the SFDL method, but the operating cost of SFDL is the highest as well. Under the optimal operation conditions, VS and ASP methods could have a moderate drug loading, and therefore, in the case when very high TD and DI are not required, VS and ASP methods can be a good alternative for SFDL due to their simpler and low-cost operation.