Study On The Aloe Oral Liquid Preparation And Pharmacological Activities

In this paper the preparation technology of aloe oral liquid were examined.Select the application of chemometrics method to study the extracting conditionsof aloe polysaccharide，According to the optimization of the proceeds of theoptimal extraction conditions are coarse polysaccharide extraction，The coarsepolysaccharide made into oral liquid，Through the comprehensive score of aloepolysaccharide oral liquid clarity， The results showed good preparationconditions，Show that the experimental science method is easy and simple，Preparation of oral liquid have good stability，In oral liquid preparation of qualitystandards。Of aloe liquid pharmacopoeia provisions under the appearance of thephysical properties、Relative density、pH、clarity、The load differenceThecorresponding check respectively，Set up quality standards。At the same time,using the phenol-sulfuric acid method for determining the content ofpolysaccharide in aloe oral liquid preparations，And the determination method ofthe content of polysaccharide in aloe oral liquid preparations on the methodologyof investigation。Research mainly for the influencing factors of experiment and acceleratedstability test, respectively for three batch of reed, will initially explore thestability of the oral liquid preparations, the influencing factors of the experimentmainly inspects the illumination and temperature, both of the major projects asnecessary to check the appearance color, clarity, pH value, relative density andthe content of polysaccharide. And accelerated stability test results showed thatthe appearance of the aloe liquid color and pH change over time there will be nosignificant difference, clarity is very good, is not going to happen thephenomenon of turbidity and precipitate, the polysaccharide content of oral liquidpreparations and relative density of slight decline phenomenon, and microbiallimit of the number of bacteria, mould and e. coli are meet the requirements ofthe pharmacopoeia, accelerated test time for6months, good stability in the timerange, so you can determine the aloe oral liquid preparations for a period of2years.Using chemical alloxan induced experimental diabetic mouse model was established, and analyzes the effect on aloe oral liquid to regulate blood sugar, theresults show that the aloe oral liquid has diabetic model mice fasting glucoselevels and alleviate the diabetic mice induced by alloxan the effect of weight loss;By the determination of glucose tolerance in mice and serum insulin, liverglycogen, and serum and liver tissue SOD, gsh-px activity and the content ofserum and liver tissue MDA, preliminary analysis of the possible mechanism offall blood sugar. The results show that the aloe oral liquid can improve diabetesmice oral glucose tolerance, promote the formation of diabetic mice liverglycogen, enhance the level of serum insulin and improving oxidation levelsincrease. Speculated that aloe liquid A fall blood sugar active mechanism mayoccur in stimulating the secretion of insulin and so on, is promoting thetransformation of the body’s glucose liver glycogen synthesis and by reducing theoxidative damage of islet cells and exert the function of lowering blood sugar.