Cyclodextrin And Its Derivatives Host - Guest Molecular Recognition Analysis Of The Research And Application

Cyciodextrin and its ramifications possess cofI'[Parativerigidity and favorable hydrophobic cawnm, they can be usedas moiecuiar hosts to recognize different kinds of organic,inorganic, biologicai moiecuies and to form host and guestcOmplexes, So they are worth studying. The main content ofthis article is as the foiiowing: the new mimetic enzymes ofschiff metai coaplexes, Which match to the cav-um ofcyciodextrin I were synthesized and the new cataiyticspectrophotometry was deveioped; A new type of host moiecuiewas prepared and used to recognize and analyse guest moiecuiesuccess ful ly.There are four chapters:l. There was a review about the deveiopment ofcyciodextrin used in moiecule recognization. The currenthotspot in cyciodextrin chefnistry was pointed out.2. Studies on the cataiytic spectrophotometry usingβ--CD--Schiff Cu (II ) comPiex as mimetic enzyffie.2 --hydroxy--i--napthaidehyde--2 --aI'nino--thiazole (HNATS )and its Cu (Ii ) compiex were designed and synthesizedaccording to the matching between naphthaiene ring andhydrophobic cavum of 6--CD. A new cataiyLic spectrophotometrywas deveioped.The effect of different kinds of surfactdntson the catalytic activity of mimetic enzrne was studied. andqariic, scaiiion and onion with satisfactory resuits.3. Studies on the cataiytic spectrophotometry using8--CDP --Schiff metai coopiex as mimet ic enzyme.Sai icyiaidelye-- 2 --anino-- 4 --phenyit;hiazoie (SAPTS ) andits metai coapiexes were designed and Eiynthesized accordingto tbe enhanced hydrophobic cavum of 0--CDP and the speciaicoope3rative action between β--CD ceiis. A new catalyticspectrophotometry was deveioped. The Proposed methoed wasused to determine superoxide dismutase (SOD) activity in ratbiood.4. The synthesization and analyticai appiication of newhost molecule. Based on the special moiecular recognitionbetween β--CDP and straight iinetype rmolecuie with doubieguest, a new host fnolecule was prepared and used to determinethe smaii guest moiecuie--Ai'+. The meclianism of doubierecognition was proposed.