Juglone And Its Derivatives

In this paper, the phannacologieal activities of juglone as a natural product were firstly reviewed. The preparation of juglone and its derivatives by the Frediel桟raft reaction of phenol and its derivatives with .succinic anhydride was reported. Condensation of 1, 4-di hydroxylbenzene with rnaleic anhydride under high temperature gave 5,8 dihydroxyl條, 4梟aphthoquinone. Its?existence as a hybrid with syrrmetric structure was detemined by analyzing of NMR. Under the same condition, 5梙ydroxyl?梞ethyl條, 4? naphthoquinone was obtained. Juglone was prepared through the oxidization of 1, 5? dihydroxylnaphthalene. The reaction of 5, 8梔ihydroxyl ?, 4梟aphthalenequinone with 1桞r?, 3, 4, 6梩etra-O--acetyl? a 桪梘lucopyanose gavel ?{}-S梙ydroxy條, 4梟aphthalene? dione?? 3? 4? 6挆tetra桹--acetyl?P 桪梘lucopyranosede. It抯 deacetylation didn抰 obtain expective result. Structures of all above compounds were detennined by IR, 1HMR, ?CMR.