Rhythm Thailand Capsule Preparation Process And Quality Standards

Cardiac arrhythmias is a deadly disease which is a clinical manifestation of coronary heart disease .Now most of the drugs for the disease are chemical drugs, such as Encainide, Flecainde, Moricizine etc. When they have curative effects to arrhythmias, they also have serious side-effects. Some even are dangerous. These disadvantages have limited the use of these drugs.Xinlvtai capsule composed of seven traditional Chinese medicine:Radix salviae mil tiorrhizae, A etc.,which all were included in the pharmacopia of China. It has similar curative effects with chemical drugs. But it has less side-effects. So the prospect is very good. When it is developed into a neo-medicine, it will be supposed to create more social and economic benefits.The essay is about the preparation procedure and quality standards of Xinlvtai capsule. Because time was limited, I hadn't finished the research of stability. The preparation procedure included extracting of volatile oil and enveloping it with B-CD. As for Radix salviae mil tiorrhizae, selecting tanshinone II A as index, I refluxed it with 50% ethanol. In research of water-extraction and ethanol-precipitation process, took sinocimenine as index. After concentrated the extract to relative density 1.18, dried into powders with spray drying. Then made granules to fill capsules. All above-mentioned procedure were chose through the orthogonal design L9(34).In the quality control study, thin layer chromatography(TLC) was used for identification of Radix salviae mil tiorrhizae, A, Radix paeoniae rubra, and the TLC's conditions were studied too. HPLC was employed for the quantitative determination of tanshinone II A.