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The Forefront Of The Capsule Developed

Posted on:2006-01-12Degree:MasterType:Thesis
Country:ChinaCandidate:M WangFull Text:PDF
GTID:2191360155976195Subject:Pharmacy
Abstract/Summary:PDF Full Text Request
Prostatitis is a common and frequently-occuring disease in the urinary and reproductive system. It is a kind of syndrome caused by different reasons. Because of the protective screen function that causes by prostate membrane of the body, antibiotics are always difficult to be absorbed in the prostate, prostatitis is difficult to take a redical cure. At present, western medical and physical treatment is still not satisfied, and the result of treatment which uses Chinese traditional medicine is very good. There are many Chinese traditional medicine that can treat prostatitis in the market, such as Qianliehuichun Capsule, Qianliexiao Capsule and etc. the experiment analyzed the clinical experienced prescription, do the experiment on extraction and preparation, established the quality standard from Chp. Part 1 and other documents, checked the stability to prove that the preparation is workable and did the test of the toxicity. The result is: Houttuynia cordata Thunb. and other two medicinal herbs use 12 hours to extract volatile oil, and use aqueous solution-stirring method to include the volatile oil. The preparation is: 60℃, stirring time is 3 hours, the ratio between β —cyclodextrin(g) :Volatile oil (ml) is 6:1. In this condition, we can get the highest extracted and included rate. Phellodendron Chinese Schneid Coptis chinensis Franch. and other six medicinal herbs adding quantity of 10 times waters boil three times to fry, 2 hours at first boiling time, 1 hour at the second and third time. Collecting the boiled solution, filter it, the filtrate concentrates until the relative consistency is 1.10~1. 15(60℃), cooling it to room temperature , then, add some ethanol to the solution to let the solution' s concentration of ethanol getting to 60%. Astragalusmembranaceus (Fisch. )Bge, var. mongholicus (Bge.) Polygonum cuspidatum and other two medicinal herbs adding the quantity of 8 times 70% athanol heat and add flowing three times, 1 hour each time. In this condition, the extractive rate is highest; established five TLC discriminations five projects of checking and a content determination standard; Did the stability test and identify the new drug is stable. The drug effect learns to show in experiment that the curative effect of Qianliebao Capsule treating prostatitis is definite. Acute toxieity experiment shows that the toxicity of Qianliebao Capsule is very small. So, the methods of preparation and quality standard are accurate and credible, there is no poisonous side effect when Taking the drug for a long time. These can be applied.
Keywords/Search Tags:Qianliebao Capsule, Prostatitis, Preparation, Quality standard, Drug effect studying, Acute toxicity experiment
PDF Full Text Request
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