Of Voglibose Its Glycosides Derivatives

Voglibose inhibits enzymes of maltose and sucrose as a kind of Glucosidase's inhibitor. The well curative effect and little side effect of Voglibose cause it being the important anti-diabetes' medicine.The preparation methods of Voglibose were summarized and Voglibose was finally synthesized from methyl glucopyranoside by ten steps. In the separation of production, recrystalization was applied in four steps' reactions, while column chromatography on silica gel was employed by the reference. According to the phenomenon and data , the mechanism of the reactions was tried to explain. Reduction-animation reaction was especially studied and its two methods were compared in this article, finding that one-step reaction was better than two-steps' for its easier operations and less loss.Seventeen different glucosides, having potential medicine activity, were prepared from tetrabenzylglucose by bromation reaction and phase transfer caltalyst reaction. Fifteen of them are new compounds. Different groups in gluco-acceptor have a great influence on total yield, it was found that electron-withdrawing group can increace the yield for its accelaration to hydrogen atom's leaving and nucleophilic substitution reaction .The high reaction activity of a-tetra benzyl bromoglucose being gluco-doner was used to react with the gluco-acceptor which was high steric hindrance. This method can be used in the solid-liquid two phase reaction, widening the application of α-tetra benzyl bromoglycose .