| Spectinomycin is a kind of antibiotics with alkalescence and water-solubility. It is also called actinospectacin. It is a family of antibiotics, which is made up of aminocyclitol (the main body) and amino-sugar- glycoside class (glycoside bond) .Spectinomycin is a broad spectrum antibiotic, which has an effect of being against gram negative and gram positive bacterium. It specialized in treating inflation caused by Neisseria gonorrhoeae in clinic. Right now Spectinomycin is the first choice of treating acute gonorrhea, taking place of penicillin. In addition, broad spectrum antibiotic effect and low-toxicity make Spectinomycin become a feed additive, to prompt the turnout of crop and the growth of livestock.In the recent years, the sex- originated disease is roaring, in which the gonorrhea take the biggest part. Comparing with the similar but uncertain and expensive medicament, Spectinomycin has the advantage of safety and being cheap. So the requirement of Spectinomycin is rising. Now Spectinomycin can be produced domestically, but we still fall behind with foreign producers in basic theory researching and production level. In order to expend the market and realize the internationalization of production, besides of attaining the certificate of GMP and FDA in foreign countries, we need to prompt the quality of our products.Above, this article focuses on three parts:(1) To optimize the acidity of pH of Spectinomycin fermentation broth, in order to remove the protein impurity much more completely. It is also in favor of acidifying the fermentation broth and reducing the titer of leftover of filter cake so as to prompt the yield.(2) To make LK-12 ionic exchanging resin take place ofLK-11 resin, in order to enhance the volume of adsorption and the titer... |
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