Functional Substituted Alkyltin Carboxylic Acid Ester Complex Synthesis, Characterization, And Nature Study

It is obviously that functionally-substituted alkylstannanes have many heteroatoms with co-ordinating abilities. Because of the complexing coordination medel of the hetertoatoms, rich and colorful structures of this type organotin appeare. In the case of the instinsic intrest ,oganotin carboxylates including organotin dithiocarbamate have become the hot area of reseach. They have been proverbially applying to catalytic, material, pesticide, curatorial areas. In this dissertation, four diferent types of functionally-substituted alkylstannanes were prepared , they had amido-cyl, alkoxycarbinic, hydroxyl, organic group respectively. Furtherly,four different types of oganotin carboxylateswere synthized, using the types of functionally-substituted alkylstannanes as subtrate to act with N-substuted amino acids and aminodithioformic acids, adding up to less than 80 compands. They were characterized by IR, NMR spectra, and 16 single structures of the typical organotin compands were determined. The antibascterial and antitumor activity of some tipical compads of every sery organotins were determined by minicalorimetry method, and possible relation between the activity and the defent structures were analylized. The dissertation contains the following works.1.Seris organotins can be abtained after treating the product synthylized by the action of triphylstanne and acylamine with halogens: Ph_3-nX_nSnCH₂CH₂CONH₂ (X=Cl,Br,I;n=1,2). Furtherly, a number of compexes were prepared: Ph_3-nX_n-1SnCH₂CH₂CONH₂(OOCCHRNHCOC₆HF₄) (R=H,Me.Bn),Ph_3-nX_n-mSnCH₂CH₂CONH₂(S₂CNR¹₂)m (m=1,2;R¹=Me,Et). The crystal structures of : Ph₂ClSnCH₂CH₂CONH₂, Ph₂ISnCH₂CH₂CONH₂, PhBr₂SnCH₂CH₂CONH₂, PhClSnCH₂CH₂CONH₂(S₂CNEt₂),PhSnCH₂CH₂CONH₂(S₂CNEt₂)₂, PhSnCH₂CH₂CONH₂(S₂CNMe₂)₂ were resolved and their coordination mode and structural features were discussed by combining spectroscopic analysis.2.With the same methed,γ-hydroxylpropyl-phylstanne halides and their dithiocarbamate were synthesized: Ph_3-nX_nSn(CH₂)₃OH,Ph_3-nX_n-mSn(CH₂)₃OH(S₂CNR¹₂)_m(m=1,2;R¹=Me,Et). The crystal structures of these compands: Ph₂BrSn(CH₂)₃OH, Ph₂BrSn(CH₂)₃OH(S₂CNEt₂), Ph₂ClSn(CH₂)₃OH(S₂CNEt₂), Ph₂ClSn(CH₂)₃OH(S₂CNMe₂),PhSn(CH₂)₃OH(S₂CNEt₂)₂ were deter determined. The date reals that most of the subtrate organotin compands of this series have a five-numbered ring structure, as the result of the intramolecular coordination. However, in the complexes the intramolecular coordination was wrecked, leading to the disappearing of five-numbered ring structure.3. A series ofβ-alkoxycarbonylethylphenyltin halides, Cl₃SnCH₂CH₂CO₂Cp, Ph_3-nX_nSnCH₂CH₂CO₂Cp (X=Cl,Br,I;n=1,2). and their dithiocarbamates, Cl_3-nSnCH₂CH₂CO₂Cp(S₂CNR¹₂)_n(n=1,2,3) were synthesized and characterized. The crystal structures of 3 compandes: PhCl₂SnCH₂CH₂CO₂C₅H₉), Cl₃SnCH₂CH₂CO₂ C₅H₉, (Et₂NCS₂)₃SnCH₂CH₂CO₂ C₅H₉ were determined.4. 2-[2-(triphyltin)-vinyl]adamantanol was prepeared through the addition action between tripylstanne and ethyl- adamantanol. The date of the products X-diffraction demonstrates that qulity of cis-isomer is more than trans-isomer.5. The antibascterrial activity of a number of compands of every series of functionally-substituted alkylstannanes and teir carboxylate complexes were determined by the minimcalorimetry methed, and possible relation between the activity and the defent structures were analylize.Bioassay results have shown that compound Ph₂ClSnCH₂CH₂CONH₂ , Ph₂BrSnCH₂CH₂CH₂OH, Ph₃SnCH=CH(ADM-2-OH), possess good in vitroantitumor activity against tumor cells C6 and A549.